OBJECTIVES To investigate the relationship between the lesion location and post-stroke restless legs syndrome (RLS). METHODS A total of 376 patients with acute cerebral infarction were recruited from Tangshan Gongren Hospital, Department of Neurology between May 2016 and May 2017, all of whom were evaluated for RLS. Established RLS was diagnosed according to the criteria of the International Restless Legs Syndrome Study Group (IRLSSG) in 2012. Neurological functions were assessed according to the National Institutes of Health Stroke Scale (NIHSS). The lesion location was evaluated with magnetic resonance imaging (MRI). The associations between the lesion location and post-stroke RLS were then analyzed by logistic regression. RESULTS A total of 49 patients (13.03%) had RLS. The multivariate logistic regression model adjusting for post-stroke RLS risk factors including gender, age, history of hypertension, history of diabetes, history of stroke, smoking, drinking, body mass index (BMI), NIHSS, hemoglobin, platelet and homocysteine determined that body of caudate nucleus and pontine were significantly associated with post-stroke RLS with odds ratio (OR) of 26.26 (95% confidence interval (CI): 9.41-73.28,p < 0.001) and OR of 4.37 (95% CI: 1.24-15.34, p = 0.021). The stepwise logistic regression model with temporal lobe, parietal lobe, occipital lobe, frontal lobe, callosum, body of caudate nucleus, thalamus, lenticulo capsule, corona radiata, centrum semi-ovale and pontine as potential predictors yielded a predictor mode. The stepwise logistic regression predictor mode indicated that body of caudate nucleus and pontine predicted post-stroke RLS with similar OR to multivariate models of 23.61 (95% CI: 9.53-58.51, p < 0.001) and 4.46 (95% CI: 1.38-14.4, p = 0.012). CONCLUSIONS The ischemic infarcts located in body of caudate nucleus, pontine are significantly associated with post-stroke RLS. Body of caudate nucleus acute infarcts may play a role in the development of post-stroke RLS.

中文翻译：

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急性中风后腿不安综合症：体尾状核的考虑。

目的探讨病灶位置与中风后躁动综合征（RLS）之间的关系。方法在2016年5月至2017年5月期间，从神经科唐山工仁医院招募了376例急性脑梗死患者，所有患者均接受了RLS评估。已建立的RLS是根据国际躁动腿综合征研究小组（IRLSSG）在2012年的标准诊断的。神经系统功能是根据美国国立卫生研究院卒中量表（NIHSS）进行评估的。通过磁共振成像（MRI）评估病变部位。然后通过逻辑回归分析病变部位与中风后RLS之间的关联。结果共有49例患者（13.03％）患有RLS。通过对卒中后RLS危险因素（包括性别，年龄，高血压史，糖尿病史，中风史，吸烟，饮酒，体重指数（BMI），NIHSS，血红蛋白，血小板和同型半胱氨酸）进行调整的多元logistic回归模型确定：尾状核和桥脑与卒中后RLS显着相关，优势比（OR）为26.26（95％置信区间（CI）：9.41-73.28，p <0.001）和OR为4.37（95％CI：1.24-） 15.34，p = 0.021）。以颞叶，顶叶，枕叶，额叶，call，尾状核体，丘脑，慢囊，电晕放射，中心半椭圆形和脑桥为潜在预测因子的逐步逻辑回归模型产生了预测因子模式。逐步logistic回归预测器模式表明尾状核和桥脑预测了卒中后RLS，其OR与多元模型23.61（95％CI：9.53-58.51，p <0.001）和4.46（95％CI：1.38-14.4）相似，p = 0.012）。结论位于尾状核，桥脑体的缺血性梗死与卒中后RLS显着相关。尾状核急性梗死体可能在中风后RLS的发展中起作用。