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Transcontinental dispersal of Anopheles gambiae occurred from West African origin via serial founder events.
Communications Biology ( IF 5.2 ) Pub Date : 2019-12-19 , DOI: 10.1038/s42003-019-0717-7
Hanno Schmidt 1 , Yoosook Lee 1 , Travis C Collier 1 , Mark J Hanemaaijer 1 , Oscar D Kirstein 1 , Ahmed Ouledi 2 , Mbanga Muleba 3 , Douglas E Norris 4 , Montgomery Slatkin 5 , Anthony J Cornel 1, 6 , Gregory C Lanzaro 1
Affiliation  

The mosquito Anopheles gambiae s.s. is distributed across most of sub-Saharan Africa and is of major scientific and public health interest for being an African malaria vector. Here we present population genomic analyses of 111 specimens sampled from west to east Africa, including the first whole genome sequences from oceanic islands, the Comoros. Genetic distances between populations of A. gambiae are discordant with geographic distances but are consistent with a stepwise migration scenario in which the species increases its range from west to east Africa through consecutive founder events over the last ~200,000 years. Geological barriers like the Congo River basin and the East African rift seem to play an important role in shaping this process. Moreover, we find a high degree of genetic isolation of populations on the Comoros, confirming the potential of these islands as candidate sites for potential field trials of genetically engineered mosquitoes for malaria control.

中文翻译:


冈比亚按蚊的横贯大陆传播是通过一系列创始人事件从西非起源发生的。



冈比亚按蚊分布在撒哈拉以南非洲的大部分地区,作为非洲疟疾媒介,具有重大的科学和公共卫生意义。在这里,我们对从西非到东非采样的 111 个样本进行了群体基因组分析,其中包括来自科摩罗大洋岛屿的第一个全基因组序列。冈比亚非洲蜥种群之间的遗传距离与地理距离不一致,但与逐步迁移的情况一致,在这种情况下,该物种通过过去约 20 万年的连续创始人事件扩大了从西非到东非的范围。刚果河流域和东非裂谷等地质屏障似乎在塑造这一过程中发挥着重要作用。此外,我们发现科摩罗的种群存在高度的基因隔离,证实了这些岛屿作为用于控制疟疾的基因工程蚊子潜在现场试验的候选地点的潜力。
更新日期:2019-12-19
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