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Insights into the κ/ι-carrageenan metabolism pathway of some marine Pseudoalteromonas species.
Communications Biology ( IF 5.2 ) Pub Date : 2019-12-19 , DOI: 10.1038/s42003-019-0721-y Andrew G Hettle 1 , Joanne K Hobbs 1 , Benjamin Pluvinage 1 , Chelsea Vickers 1, 2 , Kento T Abe 1, 3 , Orly Salama-Alber 1 , Bailey E McGuire 1 , Jan-Hendrik Hehemann 1, 4 , Joseph P M Hui 5 , Fabrice Berrue 5 , Arjun Banskota 5 , Junzeng Zhang 5 , Eric M Bottos 6 , Jonathan Van Hamme 6 , Alisdair B Boraston 1
Communications Biology ( IF 5.2 ) Pub Date : 2019-12-19 , DOI: 10.1038/s42003-019-0721-y Andrew G Hettle 1 , Joanne K Hobbs 1 , Benjamin Pluvinage 1 , Chelsea Vickers 1, 2 , Kento T Abe 1, 3 , Orly Salama-Alber 1 , Bailey E McGuire 1 , Jan-Hendrik Hehemann 1, 4 , Joseph P M Hui 5 , Fabrice Berrue 5 , Arjun Banskota 5 , Junzeng Zhang 5 , Eric M Bottos 6 , Jonathan Van Hamme 6 , Alisdair B Boraston 1
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Pseudoalteromonas is a globally distributed marine-associated genus that can be found in a broad range of aquatic environments, including in association with macroalgal surfaces where they may take advantage of these rich sources of polysaccharides. The metabolic systems that confer the ability to metabolize this abundant form of photosynthetically fixed carbon, however, are not yet fully understood. Through genomics, transcriptomics, microbiology, and specific structure-function studies of pathway components we address the capacity of newly isolated marine pseudoalteromonads to metabolize the red algal galactan carrageenan. The results reveal that the κ/ι-carrageenan specific polysaccharide utilization locus (CarPUL) enables isolates possessing this locus the ability to grow on this substrate. Biochemical and structural analysis of the enzymatic components of the CarPUL promoted the development of a detailed model of the κ/ι-carrageenan metabolic pathway deployed by pseudoalteromonads, thus furthering our understanding of how these microbes have adapted to a unique environmental niche.
中文翻译：
深入了解一些海洋假交替单胞菌的 κ/ι-卡拉胶代谢途径。
假交替单胞菌是一种全球分布的海洋相关属，可以在广泛的水生环境中找到，包括与大型藻类表面相关，它们可以利用这些丰富的多糖来源。然而，赋予这种丰富形式的光合固定碳代谢能力的代谢系统尚未完全了解。通过基因组学、转录组学、微生物学和途径成分的特定结构功能研究，我们解决了新分离的海洋假交替单胞菌代谢红藻半乳聚糖卡拉胶的能力。结果表明，κ/ι-卡拉胶特异性多糖利用基因座 (CarPUL) 使拥有该基因座的分离株能够在该基质上生长。 CarPUL 酶成分的生化和结构分析促进了假交替单胞菌部署的 κ/ι-卡拉胶代谢途径详细模型的开发，从而进一步加深了我们对这些微生物如何适应独特环境生态位的理解。
更新日期：2019-12-19
中文翻译：
深入了解一些海洋假交替单胞菌的 κ/ι-卡拉胶代谢途径。
假交替单胞菌是一种全球分布的海洋相关属，可以在广泛的水生环境中找到，包括与大型藻类表面相关，它们可以利用这些丰富的多糖来源。然而，赋予这种丰富形式的光合固定碳代谢能力的代谢系统尚未完全了解。通过基因组学、转录组学、微生物学和途径成分的特定结构功能研究，我们解决了新分离的海洋假交替单胞菌代谢红藻半乳聚糖卡拉胶的能力。结果表明，κ/ι-卡拉胶特异性多糖利用基因座 (CarPUL) 使拥有该基因座的分离株能够在该基质上生长。 CarPUL 酶成分的生化和结构分析促进了假交替单胞菌部署的 κ/ι-卡拉胶代谢途径详细模型的开发，从而进一步加深了我们对这些微生物如何适应独特环境生态位的理解。
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