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Heart failure with preserved ejection fraction: present status and future directions.
Experimental & Molecular Medicine ( IF 9.5 ) Pub Date : 2019-12-19 , DOI: 10.1038/s12276-019-0323-2 Somy Yoon 1 , Gwang Hyeon Eom 1
Experimental & Molecular Medicine ( IF 9.5 ) Pub Date : 2019-12-19 , DOI: 10.1038/s12276-019-0323-2 Somy Yoon 1 , Gwang Hyeon Eom 1
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The clinical importance of heart failure with preserved ejection fraction (HFpEF) has recently become apparent. HFpEF refers to heart failure (HF) symptoms with normal or near-normal cardiac function on echocardiography. Common clinical features of HFpEF include diastolic dysfunction, reduced compliance, and ventricular hypokinesia. HFpEF differs from the better-known HF with reduced ejection fraction (HFrEF). Despite having a "preserved ejection fraction," patients with HFpEF have symptoms such as shortness of breath, excessive tiredness, and limited exercise capability. Furthermore, the mortality rate and cumulative survival rate are as severe in HFpEF as they are in HFrEF. While beta-blockers and renin-angiotensin-aldosterone system modulators can improve the survival rate in HFrEF, no known therapeutic agents show similar effectiveness in HFpEF. Researchers have examined molecular events in the development of HFpEF using small and middle-sized animal models. This review discusses HFpEF with regard to etiology and clinical features and introduces the use of mouse and other animal models of human HFpEF.
中文翻译：
射血分数保留的心力衰竭：现状和未来方向。
射血分数保留型心力衰竭 (HFpEF) 的临床重要性最近变得明显。HFpEF 是指超声心动图显示心功能正常或接近正常的心力衰竭 (HF) 症状。HFpEF 的常见临床特征包括舒张功能障碍、顺应性降低和心室运动功能减退。HFpEF 不同于众所周知的射血分数降低的 HF (HFrEF)。尽管具有“保留的射血分数”，但 HFpEF 患者仍有呼吸短促、过度疲劳和运动能力受限等症状。此外，HFpEF 的死亡率和累积存活率与 HFrEF 一样严重。虽然 β 受体阻滞剂和肾素-血管紧张素-醛固酮系统调节剂可以提高 HFrEF 的存活率，没有已知的治疗药物在 HFpEF 中显示出类似的效果。研究人员使用中小型动物模型检查了 HFpEF 发展过程中的分子事件。本综述讨论了 HFpEF 的病因和临床特征，并介绍了人类 HFpEF 小鼠和其他动物模型的使用。
更新日期：2019-12-19
中文翻译：
射血分数保留的心力衰竭：现状和未来方向。
射血分数保留型心力衰竭 (HFpEF) 的临床重要性最近变得明显。HFpEF 是指超声心动图显示心功能正常或接近正常的心力衰竭 (HF) 症状。HFpEF 的常见临床特征包括舒张功能障碍、顺应性降低和心室运动功能减退。HFpEF 不同于众所周知的射血分数降低的 HF (HFrEF)。尽管具有“保留的射血分数”，但 HFpEF 患者仍有呼吸短促、过度疲劳和运动能力受限等症状。此外，HFpEF 的死亡率和累积存活率与 HFrEF 一样严重。虽然 β 受体阻滞剂和肾素-血管紧张素-醛固酮系统调节剂可以提高 HFrEF 的存活率，没有已知的治疗药物在 HFpEF 中显示出类似的效果。研究人员使用中小型动物模型检查了 HFpEF 发展过程中的分子事件。本综述讨论了 HFpEF 的病因和临床特征，并介绍了人类 HFpEF 小鼠和其他动物模型的使用。
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