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Enhancement of the anti-inflammatory properties of grape pomace treated by Trametes versicolor.
Food & Function ( IF 5.1 ) Pub Date : 2020-01-07 , DOI: 10.1039/c9fo02296a Ana Bucić-Kojić 1 , Fátima Fernandes , Tânia Silva , Mirela Planinić , Marina Tišma , Gordana Šelo , Darijo Šibalić , David M Pereira , Paula B Andrade
Food & Function ( IF 5.1 ) Pub Date : 2020-01-07 , DOI: 10.1039/c9fo02296a Ana Bucić-Kojić 1 , Fátima Fernandes , Tânia Silva , Mirela Planinić , Marina Tišma , Gordana Šelo , Darijo Šibalić , David M Pereira , Paula B Andrade
Affiliation
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The application of solid-state fermentation for the production of value-added products from the agro- and food-industry residues has been recently investigated greatly. The white-rot basidiomycete Trametes versicolor is a widely used fungi for the degradation lignocellulosic material in solid-state conditions. Grape pomace constitutes the major by-product of Vitis vinifera L. and is a source of compounds with recognized health benefits. In this study, a process for treating grape pomace with Trametes versicolor for 15 days under solid-state conditions was developed, and the phenolic profile and anti-inflammatory potential of the grape pomace extracts before and after treatment was studied. The anti-inflammatory potential of the grape pomace extracts was studied via tests based on the inhibition of 5-lipoxygenase and hyaluronidase, two key enzymes in inflammatory processes. A total of 24 phenolic compounds were identified and quantified by HPLC methods. With the exception of anthocyanins, an increase in phenolic acids, flavan-3-ols and the flavonol rutin was observed after a treatment period of 1-4 days with T. versicolor. Moreover, the increase in the phenolic content was accompanied by an enhancement in the anti-inflammatory activity of the grape pomace extracts, which was confirmed by the strong correlation between them. This is the first study providing evidence of the benefits of the application of fungal-based solid-state fermentation as an environmentally friendly process for the enhancement of the phenolic composition and anti-inflammatory potential of grape pomace, increasing the possibility of profiting from the great waste produced by the grape-processing industry.
中文翻译：
增强了Trametes versicolor处理的葡萄果渣的抗炎特性。
近年来，已经大量研究了将固态发酵用于从农业和食品工业残余物中生产增值产品的应用。白腐烂担子菌Trametes versicolor是在固态条件下降解木质纤维素材料的广泛使用的真菌。葡萄渣是葡萄（Vitis vinifera L.）的主要副产品，是具有公认健康益处的化合物来源。在这项研究中，开发了在固态条件下用云芝Trametes处理葡萄果渣15天的方法，并研究了处理前后葡萄果渣提取物的酚类和抗炎潜力。通过基于对5-脂氧合酶和透明质酸酶的抑制作用的测试，研究了葡萄果渣提取物的抗炎潜力，炎症过程中的两个关键酶。通过HPLC方法鉴定并定量了总共24种酚类化合物。除花色素苷外，在用杂色丁香处理1-4天后，观察到酚酸，黄烷-3-醇和黄酮醇芦丁的含量增加。而且，酚含量的增加伴随着葡萄渣提取物的抗炎活性的增强，这被它们之间的强相关性所证实。这是第一项研究，提供了证据证明使用基于真菌的固态发酵作为一种环境友好的过程，可增强葡萄果渣的酚类成分和抗炎性，
更新日期：2020-02-13
中文翻译：
增强了Trametes versicolor处理的葡萄果渣的抗炎特性。
近年来，已经大量研究了将固态发酵用于从农业和食品工业残余物中生产增值产品的应用。白腐烂担子菌Trametes versicolor是在固态条件下降解木质纤维素材料的广泛使用的真菌。葡萄渣是葡萄（Vitis vinifera L.）的主要副产品，是具有公认健康益处的化合物来源。在这项研究中，开发了在固态条件下用云芝Trametes处理葡萄果渣15天的方法，并研究了处理前后葡萄果渣提取物的酚类和抗炎潜力。通过基于对5-脂氧合酶和透明质酸酶的抑制作用的测试，研究了葡萄果渣提取物的抗炎潜力，炎症过程中的两个关键酶。通过HPLC方法鉴定并定量了总共24种酚类化合物。除花色素苷外，在用杂色丁香处理1-4天后，观察到酚酸，黄烷-3-醇和黄酮醇芦丁的含量增加。而且，酚含量的增加伴随着葡萄渣提取物的抗炎活性的增强，这被它们之间的强相关性所证实。这是第一项研究，提供了证据证明使用基于真菌的固态发酵作为一种环境友好的过程，可增强葡萄果渣的酚类成分和抗炎性，
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