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New insights into the regulatory roles of microRNAs in adult neurogenesis.
Current Opinion in Pharmacology ( IF 4.0 ) Pub Date : 2019-12-19 , DOI: 10.1016/j.coph.2019.11.003
Marta Esteves 1 , Catarina Serra-Almeida 1 , Cláudia Saraiva 1 , Liliana Bernardino 1
Affiliation  

Adult neurogenesis, the process of generation of new functional neurons from neural stem cells, occurs in the subventricular zone and the subgranular zone neurogenic niches. This neurogenic process is tightly controlled by several intrinsic factors, including microRNAs (miRNAs), a class of small non-coding RNAs, which control protein translation. MiRNAs have emerged as important regulators of both embryonic and adult neural stem cells self-renewal and proliferation, neuronal differentiation, migration, maturation and integration into the complex neuronal circuitry. Herein, we will provide a review of the most prominent and recent findings underlying the physiological regulatory role of several miRNAs during adult neurogenesis.

中文翻译:

microRNA在成人神经发生中的调控作用的新见解。

成人神经发生是从神经干细胞产生新功能神经元的过程,发生在脑室下区和颗粒下区神经源性壁ches中。这种神经源性过程受到多种内在因素的严格控制,其中包括微RNA(miRNA),这是一类小的非编码RNA,可控制蛋白质翻译。MiRNA已成为胚胎和成年神经干细胞自我更新和增殖,神经元分化,迁移,成熟以及整合到复杂神经元回路中的重要调节剂。在这里,我们将提供对成年神经发生过程中几种miRNA的生理调节作用的最主要和最新发现的综述。
更新日期:2019-12-19
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