According to the World Health Organization, over 880 million people are currently at risk of acquiring lymphatic filariasis (LF) in over 52 countries worldwide. Current approaches to control LF by 2020 are short of the anticipated goal. Several studies suggest the existence of protective immunity against LF in humans. Thus, it is possible to develop a prophylactic vaccine against LF in humans. Several potential vaccine candidates were identified and tested for their potential against LF. To date, preclinical studies suggest that it is possible to develop a prophylactic vaccine against LF. Much work needs to be done, but it is clear that a prophylactic vaccine, combined with targeted chemotherapy, is critically required for eliminating LF worldwide.

中文翻译：

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人类淋巴丝虫病疫苗开发的进展。

根据世界卫生组织的数据，目前在全球超过52个国家中，有8.8亿人处于淋巴丝虫病（LF）感染的风险中。到2020年控制LF的当前方法仍未达到预期目标。多项研究表明，人类存在针对LF的保护性免疫。因此，有可能开发针对人的LF的预防性疫苗。确定了几种潜在的疫苗候选物，并测试了它们针对LF的潜力。迄今为止，临床前研究表明可能开发出针对LF的预防性疫苗。需要做很多工作，但是很显然，在全球范围内消除LF至关重要地需要预防性疫苗与靶向化学疗法的结合。