Glycyrrhiza glabra is considered as potential drug for nasopharyngeal carcinoma (NPC). However, whether the long noncoding RNAs' (lncRNAs) contributes to the anti-cancer function of this herb is unknown. In present study, we analyzed the differential expression of lncRNA between G. glabra-treated and untreated C666-1 cells. Out of those tumor-related lncRNAs, AK027294 had a strongest down-regulation upon G. glabra treatment. Knockdown of AK027294 suppresses the proliferation of C666-1 cells by inducing the apoptosis. Moreover, either G. glabra treatment or knockdown of AK027294 significantly increases the production of EZH1 (Enhancer of zeste 1 polycomb repressive complex 2 subunit). Collectively, we have identified a potential mechanism that the down-regulation of AK027294 contributes to the anti-cancer function of G. glabra and also provide the potential inter-relationship between AK027294 and EZH1.

中文翻译：

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甘草通过抑制lncRNA AK027294的表达来抑制鼻咽癌细胞的增殖。

甘草被认为是鼻咽癌（NPC）的潜在药物。但是，长的非编码RNA's（lncRNAs）是否有助于这种草药的抗癌功能尚不清楚。在当前的研究中，我们分析了在青光眼处理过的和未处理过的C666-1细胞之间lncRNA的差异表达。在那些与肿瘤相关的lncRNA中，AK027294在G.glabra处理后具有最强的下调作用。敲击AK027294可通过诱导细胞凋亡来抑制C666-1细胞的增殖。此外，无论是G. glabra处理还是敲除AK027294均可显着提高EZH1（zeste 1聚梳阻抑复合物2亚基的增强剂）的产量。总的来说，我们已经确定了AK027294的下调有助于G的抗癌功能的潜在机制。