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Maltobionic acid accelerates recovery from iron deficiency-induced anemia in rats.
Bioscience, Biotechnology, and Biochemistry ( IF 1.4 ) Pub Date : 2019-10-12 , DOI: 10.1080/09168451.2019.1676694
Daiki Suehiro 1 , Haruka Kawase 2 , Sumire Uehara 3 , Rio Kawase 3 , Ken Fukami 1 , Tomoyuki Nakagawa 2, 3 , Masaya Shimada 2, 3 , Takashi Hayakawa 2, 3
Affiliation  

In experiments 1 and 2, effect of ingestion of maltobionic acid calcium salt (MBCa) on recovery of rats from a latent iron deficiency and from iron deficiency anemia was examined, respectively. After grouping rats into control and iron-deficiency groups, a latent iron deficiency or iron-deficiency anemia was induced in the latter group. And recovery from these states by MBCa containing diets (0%, 3%, and 6% MBCa in diet, classified into MBCa-0, MBCa-3, and MBCa-6 groups) was compared for convalescence period in light of iron sufficient control group. In experiment 1, MBCa ingestion significantly increased the iron concentration in the serum and liver, and promoted recovery from a latent iron deficiency. In experiment 2, hemoglobin and hematocrit levels increased significantly with MBCa intake, and recovery from iron-deficiency anemia was promoted. MBCa effectively promoted the recovery of rats from a subclinical iron deficiency and iron-deficiency anemia.Abbreviations: ANOVA: analysis of variance; DMT1: divalent metal transporter 1; EDTA-2Na: disodium salt of ethylenediaminetetraacetic acid; Fpn: feroportin; Hb: hemoglobin; Ht: hematocrit; ICP-OES: inductivity coupled plasma optical emission spectrometer; MBCa: maltobionic acid calcium salt; nitroso-PSAP: 2-nitroso-5-[N-n-propyl-N-(3-sulfopropyl)amino]phenol; SE: standard error; SI: serum-iron concentration; TSAT: transferrin saturation; TIBC: total iron-binding capacity; UIBC: unsaturated iron-binding capacity.

中文翻译:

麦芽糖酸加速了铁缺乏引起的贫血的恢复。

在实验1和2中,分别研究了摄入麦芽糖酸钙盐(MBCa)对大鼠从潜在铁缺乏症和从铁缺乏性贫血中恢复的作用。将大鼠分为对照组和铁缺乏症组后,在后者组中诱发了潜在的铁缺乏症或铁缺乏症性贫血。并根据铁充足的控制情况,比较了含有MBCa的饮食(饮食中0%,3%和6%MBCa,分为MBCa-0,MBCa-3和MBCa-6组)从这些状态的恢复期的恢复期。团体。在实验1中,MBCa的摄入显着增加了血清和肝脏中的铁浓度,并促进了从潜在铁缺乏症的恢复。在实验2中,血红蛋白和血细胞比容水平随MBCa摄入量的增加而显着增加,并促进了缺铁性贫血的恢复。MBCa有效促进亚临床缺铁和缺铁性贫血大鼠的康复。DMT1:二价金属转运蛋白1;EDTA-2Na:乙二胺四乙酸二钠盐;乙二胺四乙酸二钠盐。Fpn:feroportin;Hb:血红蛋白;HT:血细胞比容;ICP-OES:电感耦合等离子体发射光谱仪;MBCa:麦芽糖酸钙盐;亚硝基-PSAP:2-亚硝基-5- [Nn-丙基-N-(3-磺丙基)氨基]苯酚;SE:标准错误;SI:血清铁浓度;TSAT:转铁蛋白饱和度;TIBC:总铁结合能力;UIBC:不饱和铁的结合能力。乙二胺四乙酸二钠盐;Fpn:feroportin;Hb:血红蛋白;HT:血细胞比容;ICP-OES:电感耦合等离子体发射光谱仪;MBCa:麦芽糖酸钙盐;亚硝基-PSAP:2-亚硝基-5- [Nn-丙基-N-(3-磺丙基)氨基]苯酚;SE:标准错误;SI:血清铁浓度;TSAT:转铁蛋白饱和度;TIBC:总铁结合能力;UIBC:不饱和铁的结合能力。乙二胺四乙酸二钠盐;Fpn:feroportin;Hb:血红蛋白;HT:血细胞比容;ICP-OES:电感耦合等离子体发射光谱仪;MBCa:麦芽糖酸钙盐;亚硝基-PSAP:2-亚硝基-5- [Nn-丙基-N-(3-磺丙基)氨基]苯酚;SE:标准错误;SI:血清铁浓度;TSAT:转铁蛋白饱和度;TIBC:总铁结合能力;UIBC:不饱和铁的结合能力。
更新日期:2019-12-19
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