Benzothiazole (BTA) belongs to the heterocyclic class of bicyclic compounds. BTA derivatives possesses broad spectrum biological activities such as anticancer, antioxidant, anti-inflammatory, anti-tumour, antiviral, antibacterial, anti-proliferative, anti-diabetic, anti-convulsant, analgesic, anti-tubercular, antimalarial, anti-leishmanial, anti-histaminic and anti-fungal among others. The BTA scaffolds showed a crucial role in the inhibition of the metalloenzyme carbonic anhydrase (CA). In this review an extensive literature survey over the last decade discloses the role of BTA derivatives mainly as anticancer agents. Such compounds are effective against various types of cancer cell lines through a multitude of mechanisms, some of which are poorly studied or understood. The inhibition of tumour associated CAs by BTA derivatives is on the other hand better investigated and such compounds may serve as anticancer leads for the development of agents effective against hypoxic tumours.

中文翻译：

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苯并噻唑衍生物作为抗癌剂。


苯并噻唑（BTA）属于杂环类双环化合物。 BTA衍生物具有广谱生物活性，如抗癌、抗氧化、抗炎、抗肿瘤、抗病毒、抗菌、抗增殖、抗糖尿病、抗惊厥、镇痛、抗结核、抗疟疾、抗利什曼原虫、 - 组胺和抗真菌等。 BTA 支架在金属酶碳酸酐酶 (CA) 的抑制中发挥着至关重要的作用。在这篇综述中，对过去十年的广泛文献调查揭示了 BTA 衍生物主要作为抗癌剂的作用。此类化合物通过多种机制有效对抗各种类型的癌细胞系，其中一些机制研究或了解甚少。另一方面，BTA 衍生物对肿瘤相关 CA 的抑制作用得到了更好的研究，此类化合物可以作为抗癌先导材料，用于开发有效对抗缺氧肿瘤的药物。