BACKGROUND Regular participation in physical activity by people with cystic fibrosis (CF) promotes positive clinical and health outcomes including reduced rate of decline in lung function, fewer hospitalizations and greater wellbeing. However adherence to exercise and activity programs is low, in part due to the substantial daily therapy burden for young people with CF. Strict infection control requirements limit the role of group exercise programs that are commonly used in other clinical groups. Investigation of methods to promote physical activity in this group has been limited. The Active Online Physical Activity in Cystic fibrosis Trial (ActionPACT) is an assessor-blinded, multi-centre, randomized controlled trial designed to compare the efficacy of a novel web-based program (ActivOnline) compared to usual care in promoting physical activity participation in adolescents and young adults with CF. METHODS Adolescents and young adults with CF will be recruited on discharge from hospital for a respiratory exacerbation. Participants randomized to the intervention group will have access to a web-based physical activity platform for the 12-week intervention period. ActivOnline allows users to track their physical activity, set goals, and self-monitor progress. All participants in both groups will be provided with standardised information regarding general physical activity recommendations for adolescents and young adults. Outcomes will be assessed by a blinded assessor at baseline, after completion of the intervention, and at 3-months followup. Healthcare utilization will be assessed at 12 months from intervention completion. The primary outcome is change in moderate-to-vigorous physical activity participation measured objectively by accelerometry. Secondary outcomes include aerobic fitness, health-related quality of life, anxiety and depression and sleep quality. DISCUSSION This trial will establish whether a web-based application can improve physical activity participation more effectively than usual care in the period following hospitalization for a respiratory exacerbation. The web-based application under investigation can be made readily and widely available to all individuals with CF, to support physical activity and exercise participation at a time and location of the user's choosing, regardless of microbiological status. TRIAL REGISTRATION Clinical trial registered on July 13, 2017 with the Australian and New Zealand Clinical Trials Register at (ACTRN12617001009303).

中文翻译：

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基于网络的干预措施，促进患有囊性纤维化的青少年和年轻人的身体活动：随机对照试验方案。


背景 囊性纤维化 (CF) 患者定期参加体育活动可促进积极的临床和健康结果，包括降低肺功能下降率、减少住院次数和提高健康水平。然而，锻炼和活动计划的坚持率较低，部分原因是患有囊性纤维化的年轻人每天承受着巨大的治疗负担。严格的感染控制要求限制了其他临床群体常用的团体锻炼计划的作用。对促进该群体身体活动的方法的研究有限。囊性纤维化中的活跃在线体力活动试验 (ActionPACT) 是一项评估者盲法、多中心、随机对照试验，旨在比较新型网络程序 (ActivOnline) 与常规护理在促进囊性纤维化患者参与体力活动方面的功效。患有 CF 的青少年和年轻人。方法 患有囊性纤维化的青少年和年轻人在出院时因呼吸系统恶化而被招募。随机分配到干预组的参与者将可以在 12 周的干预期内使用基于网络的体育活动平台。 ActivOnline 允许用户跟踪他们的身体活动、设定目标并自我监控进度。两组的所有参与者都将获得有关青少年和年轻人一般身体活动建议的标准化信息。盲法评估员将在基线、干预完成后以及 3 个月随访时对结果进行评估。医疗保健利用率将在干预完成后 12 个月内进行评估。主要结果是通过加速度计客观测量的中度至剧烈身体活动参与的变化。 次要结果包括有氧健身、与健康相关的生活质量、焦虑和抑郁以及睡眠质量。讨论 该试验将确定基于网络的应用程序是否可以比常规护理更有效地改善因呼吸系统恶化住院后的身体活动参与情况。正在研究的基于网络的应用程序可以方便且广泛地提供给所有 CF 患者，以支持用户在选择的时间和地点进行身体活动和锻炼，而不管微生物状况如何。试验注册 临床试验于 2017 年 7 月 13 日在澳大利亚和新西兰临床试验注册处注册，网址为 (ACTRN12617001009303)。