BACKGROUND Observational studies examining the association between oral health and juvenile idiopathic arthritis (JIA) among children and adolescents have reported inconsistent findings. The aims of this systematic review and meta-analysis were to ascertain a potential difference in oral health and oral health-related quality of life (OHRQoL) among children and adolescents with JIA and healthy peers, and to assess the association of prevalence of oral diseases/conditions, temporomandibular disorders (TMD), including temporomandibular joint (TMJ) diseases, in relation to activity and severity of JIA. METHOD Medline Ovid, Embase, CINAHL, SweMed+ and Cochrane Library were searched up to 25 November 2018. All articles published in English, German and Scandinavian languages focusing on children and adolescents with JIA and without JIA in relation to oral health measures, were considered. Two authors independently evaluated observational studies for inclusion. The study quality was assessed using modified Newcastle Ottawa Scale. Meta-analysis was performed for studies focusing on dental caries as an outcome. RESULTS Nineteen articles met the inclusion criteria, covering a range of oral diseases/conditions and OHRQoL. Eighteen studies had cross-sectional design. No mean difference of dmft/DMFT indices (decayed/missed/filled teeth) was observed between the JIA - and healthy group. None of the oral health measures including dental erosive wear, enamel defects, dental maturation and OHRQoL, indicated better oral health among children and adolescents with JIA compared to healthy group. However, periodontal conditions and TMD were more predominant among children and adolescents with JIA compared to healthy peers. CONCLUSIONS Based on the cross-sectional studies, periodontal diseases and TMD were found to be more frequent in children and adolescents with JIA compared to healthy peers. Furthermore, more high-quality studies with large sample size are needed before we infer any concrete conclusion regarding the association between the prevalence of oral and TMJ diseases or oral conditions in relation to activity and severity of JIA.

中文翻译：

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患有幼年特发性关节炎的儿童和青少年的口腔健康 - 系统评价和荟萃分析。

背景 对儿童和青少年口腔健康与幼年特发性关节炎 (JIA) 之间关系的观察性研究报告了不一致的结果。这项系统评价和荟萃分析的目的是确定患有幼年特发性关节炎的儿童和青少年与健康同龄人在口腔健康和口腔健康相关生活质量 (OHRQoL) 方面的潜在差异，并评估口腔疾病患病率之间的关联/ 颞下颌疾病 (TMD)，包括颞下颌关节 (TMJ) 疾病，与 JIA 的活动度和严重程度相关。方法 检索截至 2018 年 11 月 25 日的 Medline Ovid、Embase、CINAHL、SweMed+ 和 Cochrane 图书馆。所有以英语、德语和斯堪的纳维亚语言发表的文章均纳入考虑，重点关注患有 JIA 和未患 JIA 的儿童和青少年，并与口腔健康措施相关。两位作者独立评估了观察性研究是否纳入。研究质量使用改良的纽卡斯尔渥太华量表进行评估。对以龋齿为结果的研究进行了荟萃分析。结果 19 篇文章符合纳入标准，涵盖一系列口腔疾病/病症和 OHRQoL。十八项研究采用横断面设计。JIA 组和健康组之间没有观察到 dmft/DMFT 指数（蛀牙/缺失/补牙）的平均差异。包括牙齿侵蚀磨损、牙釉质缺陷、牙齿成熟度和 OHRQoL 在内的所有口腔健康指标均表明，与健康组相比，幼年特发性关节炎儿童和青少年的口腔健康状况更好。然而，与健康同龄人相比，患有 JIA 的儿童和青少年的牙周疾病和 TMD 更为突出。结论 根据横断面研究，与健康同龄人相比，患有 JIA 的儿童和青少年更容易患牙周病和 TMD。此外，在我们推断出关于口腔和颞下颌关节疾病的患病率或口腔状况与幼年特发性关节炎活动性和严重程度之间的关系的任何具体结论之前，需要进行更多大样本的高质量研究。