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Day-to-day blood pressure variability is associated with lower cognitive performance among the Japanese community-dwelling oldest-old population: the SONIC study
Hypertension Research ( IF 5.4 ) Pub Date : 2019-12-19 , DOI: 10.1038/s41440-019-0377-5
Kayo Godai 1 , Mai Kabayama 1 , Yasuyuki Gondo 2 , Saori Yasumoto 2 , Toshiaki Sekiguchi 1 , Tomoko Noma 1 , Kentaro Tanaka 1 , Eri Kiyoshige 1 , Yuya Akagi 1 , Ken Sugimoto 3 , Hiroshi Akasaka 3 , Yoichi Takami 3 , Yasushi Takeya 3 , Koichi Yamamoto 3 , Yasumichi Arai 4 , Yukie Masui 5 , Tatsuro Ishizaki 5 , Kazunori Ikebe 6 , Michihiro Satoh 7 , Kei Asayama 8, 9 , Takayoshi Ohkubo 8, 9 , Hiromi Rakugi 3 , Kei Kamide 1, 3 ,
Affiliation  

Although high blood pressure (BP) and BP variability have been reported to be associated with cognitive impairment, few studies have investigated the association between home BP (HBP) and cognitive function in the oldest-old. The aim of this study was to evaluate whether the value of and the day-to-day variability in HBP was associated with cognitive function in a Japanese community-dwelling oldest-old population. Among 111 participants aged 85–87 years, cognitive function was assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA-J). HBP was measured two times every morning for a median of 30 days. The value of and variability in HBP were calculated as the average and coefficient of variation (CV) of the measurements, respectively. The associations of HBP variability with MoCA-J were examined using multiple linear regression models. Of 111 participants, 47.7% were men, and 64.0% were taking medications for hypertension. The mean HBP was 141.9 ± 14.8/72.2 ± 8.4 mmHg, and the mean CV of HBP was 6.7 ± 1.9/6.8 ± 2.4. The mean total MoCA-J score was 22.9 ± 3.5. The MoCA-J score was significantly lower with increasing CVs of both systolic BP ( b = −0.36, p = 0.034) and diastolic BP ( b = −0.26, p = 0.046) after adjustment for possible confounding factors. The value of HBP was not associated with MoCA-J. In the community-dwelling oldest-old population, higher day-to-day HBP variability, but not the value of HBP, was associated with cognitive impairment. When measuring HBP, attention should be paid not only to the values but also to their variations.

中文翻译:

在日本社区居住的老年人口中,日常血压变化与较低的认知能力有关:SONIC 研究

尽管据报道高血压 (BP) 和血压变异性与认知障碍有关,但很少有研究调查家庭血压 (HBP) 与老年人认知功能之间的关联。本研究的目的是评估 HBP 的价值和日常变异是否与日本社区居住的老年人口的认知功能有关。在 85-87 岁的 111 名参与者中,使用日语版的蒙特利尔认知评估 (MoCA-J) 评估认知功能。HBP 每天早上测量两次,中位数为 30 天。HBP 的值和变异性分别计算为测量值的平均值和变异系数 (CV)。使用多元线性回归模型检查 HBP 变异性与 MoCA-J 的关联。在 111 名参与者中,47.7% 是男性,64.0% 正在服用高血压药物。平均 HBP 为 141.9 ± 14.8/72.2 ± 8.4 mmHg,HBP 平均 CV 为 6.7 ± 1.9/6.8 ± 2.4。MoCA-J 的平均总分为 22.9 ± 3.5。在调整可能的混杂因素后,随着收缩压 (b = -0.36, p = 0.034) 和舒张压 (b = -0.26, p = 0.046) 的 CV 增加,MoCA-J 评分显着降低。HBP 的值与 MoCA-J 无关。在居住在社区的高龄人群中,较高的日常 HBP 变异性(而非 HBP 的值)与认知障碍相关。在测量 HBP 时,不仅要注意数值,还要注意它们的变化。47.7% 是男性,64.0% 正在服用高血压药物。平均 HBP 为 141.9 ± 14.8/72.2 ± 8.4 mmHg,HBP 平均 CV 为 6.7 ± 1.9/6.8 ± 2.4。MoCA-J 的平均总分为 22.9 ± 3.5。在调整可能的混杂因素后,随着收缩压 (b = -0.36, p = 0.034) 和舒张压 (b = -0.26, p = 0.046) 的 CV 增加,MoCA-J 评分显着降低。HBP 的值与 MoCA-J 无关。在居住在社区的高龄人群中,较高的日常 HBP 变异性(而非 HBP 的值)与认知障碍相关。在测量 HBP 时,不仅要注意数值,还要注意它们的变化。47.7% 是男性,64.0% 正在服用高血压药物。平均 HBP 为 141.9 ± 14.8/72.2 ± 8.4 mmHg,HBP 平均 CV 为 6.7 ± 1.9/6.8 ± 2.4。MoCA-J 的平均总分为 22.9 ± 3.5。在调整可能的混杂因素后,随着收缩压 (b = -0.36, p = 0.034) 和舒张压 (b = -0.26, p = 0.046) 的 CV 增加,MoCA-J 评分显着降低。HBP 的值与 MoCA-J 无关。在居住在社区的高龄人群中,较高的日常 HBP 变异性(而非 HBP 的值)与认知障碍相关。在测量 HBP 时,不仅要注意数值,还要注意它们的变化。8±2.4。MoCA-J 的平均总分为 22.9 ± 3.5。在调整可能的混杂因素后,随着收缩压 (b = -0.36, p = 0.034) 和舒张压 (b = -0.26, p = 0.046) 的 CV 增加,MoCA-J 评分显着降低。HBP 的值与 MoCA-J 无关。在居住在社区的高龄人群中,较高的日常 HBP 变异性(而非 HBP 的值)与认知障碍相关。在测量 HBP 时,不仅要注意数值,还要注意它们的变化。8±2.4。MoCA-J 的平均总分为 22.9 ± 3.5。在调整可能的混杂因素后,随着收缩压 (b = -0.36, p = 0.034) 和舒张压 (b = -0.26, p = 0.046) 的 CV 增加,MoCA-J 评分显着降低。HBP 的值与 MoCA-J 无关。在居住在社区的高龄人群中,较高的日常 HBP 变异性(而非 HBP 的值)与认知障碍相关。在测量 HBP 时,不仅要注意数值,还要注意它们的变化。在居住在社区的高龄人群中,较高的日常 HBP 变异性(而非 HBP 的值)与认知障碍相关。在测量 HBP 时,不仅要注意数值,还要注意它们的变化。在居住在社区的高龄人群中,较高的日常 HBP 变异性(而非 HBP 的值)与认知障碍相关。在测量 HBP 时,不仅要注意数值,还要注意它们的变化。
更新日期:2019-12-19
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