Endocannabinoid system and cyclooxygenase enzymes are implicated in neuroinflammation-induced cognitive impairment. It is believed that non-pharmacological treatments such as physical exercise affect neural systems that control behavioral responses. This research examined the effects of treadmill aerobic exercise on the expression of cannabinoid receptors and cyclooxygenases against LPS-induced cognitive disorders in the hippocampus tissue of rats. For this purpose, rats received intraperitoneal injection of 0.25 mg/kg LPS or saline for 9 continuous days before exercise training. They again received a single i.p. injection with 0.5 mg/kg LPS or saline on days 20 and 41 after the beginning of exercise. The exercise groups were forced to run on a motorized treadmill 5 days per week for 8 weeks. After the last exercise training session, the water maze test was conducted to measure cognitive function. Finally, the hippocampus tissue samples of rats were removed and used to determine the levels of gene expression using the Real-Time PCR method. Data showed that the LPS-treated rats had longer escape distance and longer escape latency to reach the hidden platform and they spent less time than the other groups in the target quadrant, but exercise training improved them in the LPS + Exe (LPS + exercise) group. Exercise increased the expression of CB1 receptor in the Sal + Exe (saline + exercise) group and reduced the expression of CB2 receptor, COX-2 and mPGES-1 in the LPS + Exe group compared to the Sal + LPS group. The findings indicate that treadmill exercise may be beneficial for improvement of cognitive function by modulating the neuroinflammatory processes.

中文翻译：

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跑步机运动可通过内源性大麻素受体和环氧合酶改善LPS引起的记忆障碍。

内源性大麻素系统和环氧合酶与神经炎症引起的认知障碍有关。据信，诸如体育锻炼之类的非药物治疗会影响控制行为反应的神经系统。这项研究研究了跑步机上的有氧运动对大麻脂受体和环氧合酶表达的影响，这些受体对抗脂多糖诱导的大鼠海马组织认知障碍。为此，在运动训练之前，大鼠连续9天接受腹膜内注射0.25 mg / kg LPS或盐水。开始运动后的第20和41天，他们再次接受0.5 mg / kg LPS或盐水的单次腹膜内注射。运动组被迫每周5天​​在电动跑步机上跑步8周。在上一次运动训练课程之后，进行水迷宫测试以测量认知功能。最后，取出大鼠海马组织样品，并使用实时PCR方法将其用于确定基因表达水平。数据显示，经LPS治疗的大鼠具有更长的逃逸距离和更长的逃逸潜伏时间，以到达隐藏平台，并且它们比目标象限中的其他组花费更少的时间，但是运动训练改善了LPS + Exe（LPS +运动）的能力。团体。与Sal + LPS组相比，运动增加了Sal + Exe（盐+运动）组中CB1受体的表达，并降低了LPS + Exe组中CB2受体，COX-2和mPGES-1的表达。研究结果表明，跑步机锻炼可能通过调节神经炎症过程而有助于改善认知功能。