Although the genetic influence on global stopping has been extensively investigated, little is known about the genetic contribution to other more complex forms of inhibitory control such as selective stopping. The selectivity of inhibitory control can be assessed by using the stimulus-selective stop-signal task. Notably, recent behavioural and neural evidence indicates that individuals can adopt selective but also non-selective stopping strategies to solve it. This study aimed to investigate for the first time the influence of two relevant dopaminergic polymorphisms (in COMT and DRD2 genes) on stimulus-selective stopping in a sample of 529 adults. Results showed that although none of these polymorphisms (neither individually nor in combination) modulate the latency of the stop process in each strategy (the stop-signal reaction time), the choice of strategy was influenced by their interaction. These results suggest that dopaminergic polymorphisms might influence strategy adoption in selective stopping paradigms, which constitutes a novel finding.

中文翻译：

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多巴胺能多态性对选择性终止的影响。

尽管已经广泛研究了遗传对全局停止的影响，但对遗传对其他更复杂形式的抑制控制（如选择性停止）的贡献知之甚少。抑制控制的选择性可以通过使用刺激选择性停止信号任务来评估。值得注意的是，最近的行为和神经证据表明，个人可以采用选择性但非选择性的停止策略来解决这一问题。这项研究旨在首次调查两种相关的多巴胺能多态性（在COMT和DRD2基因中）对529名成人样本中刺激选择性停止的影响。结果表明，尽管这些多态性（无论是单独还是组合）都不能调节每种策略中停止过程的延迟（停止信号反应时间），策略的选择受其相互作用的影响。这些结果表明，多巴胺能多态性可能影响选择性停止范式中策略的采用，这构成了一个新发现。