Skin is arguably the largest organ of the body and is continuously subjected to intrinsic, extrinsic, and environmental stresses. Therefore, skin developed elaborate mechanisms to maintain homeostasis, including antioxidant, antiinflammatory, and DNA damage repair capabilities. However, repeated and excessive stresses can overwhelm these systems, causing serious cutaneous damages, including skin carcinogenesis. Phytonutrients present in the diet possess a myriad of health-promoting effects by protecting skin from damaging free radicals as well as by other mechanisms. Although many chemoprotective phytonutrients have been shown to be efficacious individually, a combination of multiple agents could have synergistic response in curtailing or preventing cutaneous damages. Here, we discuss the benefits of natural amalgamation of phytonutrients in select fruits against skin damage including carcinogenesis. However, a majority of these studies have been done in preclinical models. Therefore, clinical studies are needed to determine the human relevance of the available preclinical data, especially in the human population who are at higher risk for skin cancers (e.g., organ transplant patients). In addition, detailed well-structured preclinical animal studies in the models of high-risk skin carcinogenesis could also be useful toward informing the design for human trials.

皮肤可以说是人体最大的器官，并且不断受到内在，外在和环境的压力。因此，皮肤开发出了精细的机制来维持体内平衡，包括抗氧化，抗炎和DNA损伤修复功能。但是，反复和过度的压力会使这些系统不堪重负，导致严重的皮肤损害，包括皮肤癌变。饮食中存在的植物营养素通过保护皮肤免受自由基的破坏以及其他机制，具有多种促进健康的作用。尽管已显示许多化学保护性植物营养素单独有效，但多种药物的组合在减少或预防皮肤损害方面可能具有协同作用。这里，我们讨论了在某些水果中自然融合植物营养素对皮肤损害（包括致癌作用）的益处。但是，这些研究大多数是在临床前模型中完成的。因此，需要临床研究来确定可用的临床前数据与人类的相关性，尤其是在那些罹患皮肤癌风险较高的人群（例如器官移植患者）中。此外，在高风险皮肤致癌模型中详细的结构良好的临床前动物研究也可能有助于为人体试验设计提供参考。特别是在罹患皮肤癌的风险较高的人群中（例如器官移植患者）。此外，在高风险皮肤致癌模型中详细的结构良好的临床前动物研究也可能有助于为人体试验设计提供参考。特别是在罹患皮肤癌的风险较高的人群中（例如器官移植患者）。此外，在高风险皮肤致癌模型中详细的结构良好的临床前动物研究也可能有助于为人体试验设计提供参考。