AIMS This pilot study aimed to evaluate differences in glycemic parameters between patients with prediabetes and normocalcemic primary hyperparathyroidism (NPHPT) and controls with prediabetes and normal parathyroid hormone (PTH) and calcium concentrations. METHODS 20 patients with NPHPT and prediabetes and 42 age-, gender-, and body mass index-matched controls with prediabetes were included. Glycemic parameters [fasting glucose (fGlu), glycosylated hemoglobin (HbA1c), fasting insulin (fIns)] were evaluated. Homeostasis Model Assessment was used for estimating insulin secretion (HOMA-B) and resistance (HOMA-IR). Participants underwent a 75-g oral glucose tolerance test. RESULTS HbA1c (5.9 ± 0.0 vs 5.9 ± 0.0%, p = 0.44), HOMA-IR (3.7 ± 1.2 vs 2.9 ± 0.2, p = 0.48), HOMA-B (117.8 ± 31.8 vs 146.9 ± 22.0%, p = 0.14), fIns (14.0 ± 4.3 vs 12.2 ± 1.1 μIU/ml, p = 0.53) and 2-hour post-load glucose concentrations (157.2 ± 2.2 vs 152.2 ± 2.0 mg/dl, p = 0.07), were nondifferent in the two groups. Higher fGlu levels were evident in the NPHPT, compared to the control group (105.6 ± 2.8 vs 98.2 ± 1.8 mg/dl, p = 0.01). fGlu demonstrated a positive correlation with PTH concentrations (rho = 0.374, p = 0.005). CONCLUSIONS Individuals with NPHPT and prediabetes present an unfavorable glycemic profile compared to age-matched people with prediabetes, suggesting a direct adverse effect of elevated PTH on glucose homeostasis.

中文翻译：

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一项前瞻性研究表明，正常血钙原发性甲状旁腺功能亢进症和糖尿病前期个体的甲状旁腺激素增加与空腹血糖升高有关。

目的该初步研究旨在评估糖尿病前期和正常钙化原发性甲状旁腺功能亢进症（NPHPT）患者与糖尿病前期和正常甲状旁腺激素（PTH）和钙浓度对照者之间血糖参数的差异。方法包括20例NPHPT和前驱糖尿病患者，以及42例年龄，性别和体重指数匹配的前驱糖尿病患者。评估了血糖参数[空腹血糖（fGlu），糖基化血红蛋白（HbA1c），空腹胰岛素（fIns）]。稳态模型评估用于估计胰岛素分泌（HOMA-B）和抵抗力（HOMA-IR）。参加者进行了75克口服葡萄糖耐量测试。结果HbA1c（5.9±0.0 vs 5.9±0.0％，p = 0.44），HOMA-IR（3.7±1.2 vs 2.9±0.2，p = 0.48），HOMA-B（117.8±31.8 vs 146.9±22.0％，p = 0.14） ），fIns（14.0±4.3与12.2±1。在两组中，1μIU/ ml，p = 0.53）和2小时负荷后葡萄糖浓度（157.2±2.2 vs 152.2±2.0 mg / dl，p = 0.07）无差异。与对照组相比，NPHPT中明显有较高的fGlu水平（105.6±2.8 vs 98.2±1.8 mg / dl，p = 0.01）。fGlu与PTH浓度呈正相关（rho = 0.374，p = 0.005）。结论与年龄相匹配的糖尿病前期人群相比，患有NPHPT和糖尿病前期的人的血糖状况不佳，这表明PTH升高对葡萄糖稳态的直接不利影响。fGlu与PTH浓度呈正相关（rho = 0.374，p = 0.005）。结论与年龄相匹配的糖尿病前期人群相比，患有NPHPT和糖尿病前期的人的血糖状况不佳，这表明PTH升高对葡萄糖稳态的直接不利影响。fGlu与PTH浓度呈正相关（rho = 0.374，p = 0.005）。结论与年龄相匹配的糖尿病前期人群相比，患有NPHPT和糖尿病前期的人的血糖状况不佳，这表明PTH升高对葡萄糖稳态的直接不利影响。