The Role of Gut Microbiota in Host Lipid Metabolism: An Eye on Causation and Connection,Small Methods

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The Role of Gut Microbiota in Host Lipid Metabolism: An Eye on Causation and Connection
Small Methods ( IF 10.7 ) Pub Date : 2019-12-19 , DOI: 10.1002/smtd.201900604
Kai Wang _{1,

2,

3} , Xianyi Liang _{1,

2,

3} , Yanli Pang ₁ , Changtao Jiang _{1,

2,

3,

4}

Affiliation

Lipid‐metabolism‐related disorders are increasingly prevalent and represent growing challenges in terms of prevention and treatment due to their complex and multifactorial pathogenesis. Recently, mounting evidence has suggested that gut microbiota play a crucial role in the regulation of lipid metabolism, which affects the development of lipid‐metabolism‐related disorders. Furthermore, increasingly precise mechanisms underlying the crosstalk between gut microbiota and lipid metabolism have been revealed and may largely deepen the understanding of microbiome. Herein, this paper reviews the relationship between microbiome and host lipid metabolism. First, the correlation between gut microbiota and different lipid metabolism disorders is described. Several causal microbes involved in pathogenesis and disease alleviation are also listed and introduced. Then, the molecular mechanisms involved in microbiome–host crosstalk are briefly discussed. Finally, ceramide, a critical metabolite that connects microbial signals to distal organs, is introduced as the messenger in organ communication.

中文翻译：

肠道菌群在宿主脂质代谢中的作用：因果关系研究

脂质代谢相关疾病由于其复杂和多因素的发病机理而日益流行，并且在预防和治疗方面面临着日益严峻的挑战。最近，越来越多的证据表明，肠道菌群在脂质代谢的调节中起着至关重要的作用，这会影响与脂质代谢相关的疾病的发展。此外，已经揭示了肠道微生物群和脂质代谢之间串扰的日益精确的机制，并且可能在很大程度上加深了对微生物组的了解。在此，本文综述了微生物组与宿主脂质代谢之间的关系。首先，描述了肠道菌群与不同脂质代谢紊乱之间的相关性。还列出并介绍了几种与发病机理和疾病缓解有关的病原微生物。然后，简要讨论了涉及微生物群-宿主串扰的分子机制。最后，神经酰胺是一种将微生物信号连接至远端器官的重要代谢物，被作为器官通讯中的信使。

更新日期：2019-12-19

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