Improved Fluorescence and Brightness of Near-Infrared and Shortwave Infrared Emitting Polymer Dots for Bioimaging Applications,ACS Applied Polymer Materials

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Improved Fluorescence and Brightness of Near-Infrared and Shortwave Infrared Emitting Polymer Dots for Bioimaging Applications
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2019-12-31 , DOI: 10.1021/acsapm.9b00967
Hubert Piwoński ₁ , Wei Li ₂ , Yang Wang ₂ , Tsuyoshi Michinobu ₂ , Satoshi Habuchi ₁

Affiliation

Development of near-infrared (NIR) and shortwave infrared (SWIR) emitting fluorophores is central to the fluorescence-based bioimaging. While conjugated polymer nanoparticles (polymer dots) are one of the promising fluorophores for this application, obtaining polymer dots that show bright fluorescence, especially in the SWIR wavelength region, has been challenging. Here, we report a generalized approach to obtain bright polymer dots through a systematic characterization of photophysical properties of NIR and SWIR emitting polymer dots. Detailed photophysical characterization of a series of polymer dots fabricated using polycarbazole- (PCz-) based conjugated polymers that adopt bent and twisted conformation reveals that the fluorescence brightness of the PCz-based polymer dots is determined by subtle balance between fluorescence quenching due to polymer chain interaction inside the particles and the twisting between the donor and acceptor moieties of the conjugated polymers inside the particles. Our results provide important insight into the rational design of highly fluorescing SWIR-emitting polymer dots.

中文翻译：

改进的近红外和短波红外发光聚合物点的荧光和亮度，用于生物成像应用

发射近红外（NIR）和短波红外（SWIR）荧光团的开发对于基于荧光的生物成像至关重要。尽管共轭聚合物纳米颗粒（聚合物点）是用于该应用的有希望的荧光团之一，但要获得显示出明亮荧光的聚合物点（尤其是在SWIR波长范围内）却具有挑战性。在这里，我们报告了一种通过对NIR和SWIR发射聚合物点的光物理特性进行系统表征来获得亮聚合物点的通用方法。使用采用弯曲和扭曲构象的基于聚咔唑-（PCz-）的共轭聚合物制备的一系列聚合物点的详细光物理特性表明，基于聚合物链的荧光猝灭之间的微妙平衡决定了基于PCz的聚合物点的荧光亮度粒子内部的相互作用以及粒子内部共轭聚合物的供体和受体部分之间的扭曲。我们的结果为高度发荧光的发射SWIR的聚合物点的合理设计提供了重要的见识。

更新日期：2020-01-01

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