The selective clearance of cellular components by macroautophagy (hereafter autophagy) is critical for maintaining cellular homeostasis. In this punctum, we summarize and discuss our recent findings regarding a novel type of selective autophagy that targets centriolar satellites (CS) for degradation, a process we termed doryphagy from the Greek word "doryphoros", standing for "satellite". CS are microtubule-associated protein complexes that regulate centrosome composition. We show that CS degradation is mediated through a direct interaction between GABARAPs and an LC3-interacting region (LIR) motif in the CS protein PCM1. Autophagy-deficient systems accumulate large abnormal CS and consequently display centrosome reorganization and abnormal mitoses. Our findings provide a mechanistic link between autophagy deficiency and centrosome abnormalities and exemplify how mammalian Atg8-family proteins (mATG8s) can regulate substrate specificity.

中文翻译：

---

猎云：自噬，一种选择性自噬的形式，会使星状卫星退化。

宏观自噬（以下称自噬）对细胞成分的选择性清除对于维持细胞稳态是至关重要的。在这一点上，我们总结并讨论了我们有关新型新型选择性自噬的最新发现，该选择性自噬以中心粒卫星（CS）为目标，该过程被希腊语“ doryphoros”称为“自噬”，代表“卫星”。CS是微管相关的蛋白质复合物，可调节中心体的组成。我们表明CS降解是通过GABARAPs和CS蛋白PCM1中的LC3相互作用区域（LIR）主题之间的直接相互作用来介导的。自噬缺陷系统会积聚大量异常CS，因此会显示中心体重组和异常有丝分裂。