Investigating Bacterial Penetration of the Blood-Brain Barrier for the Pathogenesis, Prevention, and Therapy of Bacterial Meningitis.,ACS Infectious Diseases

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Investigating Bacterial Penetration of the Blood-Brain Barrier for the Pathogenesis, Prevention, and Therapy of Bacterial Meningitis.
ACS Infectious Diseases ( IF 4.0 ) Pub Date : 2019-12-18 , DOI: 10.1021/acsinfecdis.9b00319
Kwang Sik Kim ₁

Affiliation

The most distressing aspect of bacterial meningitis is limited improvement in the mortality and morbidity despite attributable advances in antimicrobial chemotherapy and supportive care. A major contributing factor to such mortality and morbidity is our incomplete understanding of the pathogenesis of this disease. Microbial penetration of the blood-brain barrier, a prerequisite for the development of bacterial meningitis, exploits specific host and bacterial factors as well as host cell signaling molecules. Determination and characterization of such host and bacterial factors have been instrumental for developing our current knowledge on the pathogenesis of bacterial meningitis. In addition, counteracting such host and microbial factors has been shown to be efficacious in the prevention of bacterial meningitis. Antimicrobial therapy alone has limited efficacy in improving the outcome of bacterial meningitis. Recent studies suggest that counteracting targets contributing to bacterial penetration of the blood-brain barrier are a beneficial therapeutic adjunct to antimicrobial therapy in improving the outcome of bacterial meningitis. Taken together, these findings indicate that the elucidation of host and bacterial factors contributing to microbial penetration of the blood-brain barrier provides a novel strategy for investigating the pathogenesis, prevention, and therapy of bacterial meningitis.

中文翻译：

研究细菌性脑膜炎的发病机理，预防和治疗方法对血脑屏障的细菌渗透作用。

细菌性脑膜炎最令人困扰的方面是尽管在抗菌化学疗法和支持治疗方面取得了一定进展，但死亡率和发病率的改善有限。导致此类死亡率和发病率的主要因素是我们对这种疾病的发病机理的不完全了解。血脑屏障的微生物渗透是细菌性脑膜炎发展的先决条件，它利用特定的宿主和细菌因子以及宿主细胞信号分子。这些宿主和细菌因素的测定和表征对于发展我们目前关于细菌性脑膜炎的发病机理的知识是有帮助的。另外，已经表明，对抗这种宿主和微生物因素在预防细菌性脑膜炎方面是有效的。单独的抗菌疗法在改善细菌性脑膜炎的预后方面效果有限。最近的研究表明，抵消有助于血脑屏障细菌渗透的靶标是改善细菌性脑膜炎结局的抗微生物治疗的有益治疗辅助手段。综上所述，这些发现表明，阐明有助于微生物渗透血脑屏障的宿主和细菌因素，为研究细菌性脑膜炎的发病机理，预防和治疗提供了一种新颖的策略。最近的研究表明，抵消有助于血脑屏障细菌渗透的靶标是改善细菌性脑膜炎结局的抗微生物治疗的有益治疗辅助手段。综上所述，这些发现表明，阐明有助于微生物渗透血脑屏障的宿主和细菌因素，为研究细菌性脑膜炎的发病机理，预防和治疗提供了一种新颖的策略。最近的研究表明，抵消有助于血脑屏障细菌渗透的靶标是改善细菌性脑膜炎结局的抗微生物治疗的有益治疗辅助手段。综上所述，这些发现表明，阐明有助于微生物渗透血脑屏障的宿主和细菌因素，为研究细菌性脑膜炎的发病机理，预防和治疗提供了一种新颖的策略。

更新日期：2019-12-19

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