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Polychlorinated biphenyls (PCB) and organochlorine pesticides (OCP) in blood plasma - Results of the German environmental survey for children and adolescents 2014-2017 (GerES V).
International Journal of Hygiene and Environmental Health ( IF 4.5 ) Pub Date : 2019-12-18 , DOI: 10.1016/j.ijheh.2019.113426
Nicole Bandow 1 , André Conrad 2 , Marike Kolossa-Gehring 2 , Aline Murawski 2 , George Sawal 1
Affiliation  

The German Environmental Survey for Children and Adolescents 2014–2017 (GerES V) investigated the current internal exposure to polychlorinated biphenyls (PCB) and organochlorine pesticides (OCP). These analyses were carried out for a population-representative sub-sample of 1135 children and adolescents (aged 3–17 years) of all 2394 GerES V participants.

Blood plasma samples were analyzed for seven indicator PCB (PCB 28, PCB 52, PCB 101, PCB 118, PCB 138, PCB 153 and PCB 180) and selected OCP (hexachlorobenzene, three hexachlorocyclohexane isomers, 4,4′-DDT, 4,4′-DDD and 4,4′-DDE). Despite risk mitigation measures and bans put into force some decades ago children and adolescents living in Germany are still exposed to PCB and OCP: Highest geometric mean plasma concentrations were measured for 4,4′-DDE (0.158 μg/L), followed by PCB 138 (0.049 μg/L), PCB 153 (0.066 μg/L) and PCB 180 (0.032 μg/L). Different application patterns of compounds between former East and former West Germany are still reflected by differences in plasma concentrations. Significant differences between age groups and by sexes were found. Moreover, the influence of breastfeeding and fish consumption, which was also found in other studies, was confirmed.

Comparison with the results of GerES 2003–2006 confirms a decreasing trend in blood samples observed world-wide. Currently, health-based guidance values for PCB are still exceeded, though to a very limited extent. Also, the widespread occurrence of these compounds underlines the need for further monitoring of these compounds in humans although they are no longer marketed.



中文翻译:

血浆中的多氯联苯(PCB)和有机氯农药(OCP)-2014-2017年德国儿童和青少年环境调查的结果(GerES V)。

2014-2017年德国儿童和青少年环境调查(GerES V)调查了当前内部暴露于多氯联苯(PCB)和有机氯农药(OCP)的情况。对所有2394名GerES V参与者的1135名儿童和青少年(3至17岁)的人口代表性子样本进行了这些分析。

分析血浆样品中的七种指示剂PCB(PCB 28,PCB 52,PCB 101,PCB 118,PCB 138,PCB 153和PCB 180)和所选的OCP(六氯苯,三种六氯环己烷异构体,4,4'-DDT,4, 4'-DDD和4,4'-DDE)。尽管采取了降低风险的措施并于数十年前实施了禁令,但居住在德国的儿童和青少年仍暴露于PCB和OCP中:血浆最高几何平均浓度为4,4'-DDE(0.158μg/ L),其次是PCB 138(0.049μg/ L),PCB 153(0.066μg/ L)和PCB 180(0.032μg/ L)。血浆浓度的差异仍然反映了前东德与前西德之间化合物的不同施用方式。发现年龄组之间和性别之间存在显着差异。此外,母乳喂养和鱼类消费的影响,

与2003–2006年GerES的结果进行比较,证实了在全世界范围内观察到的血液样本呈下降趋势。目前,PCB的基于健康的指导值仍被超出,尽管程度非常有限。同样,这些化合物的广泛出现强调了对这些化合物在人中的进一步监测的需要,尽管它们已经不再销售。

更新日期:2019-12-18
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