Background Successful cancer treatment can lead to cancer survivors being predisposed to an increased lifelong risk of adverse late health effects. Therefore, high-quality cancer survivorship care to earlier detect and treat late effects or to preserve survivor's health is essential. Nevertheless, this care needs to be sustainable and cost-effective as well. We developed three different screen-to-screen nurse-led eHealth interventions for survivors of childhood, adolescent and young adult-onset cancer, collectively called the REVIVER interventions. Elaborating on person-centred care principles with content based on cognitive behavioural therapy modules and/or motivational interviewing techniques, these interventions aim to empower and coach survivors to improve (1) symptoms of cancer-related fatigue, (2) self-efficacy and self-management or (3) lifestyle. With the REVIVER study, we aim to evaluate the interventions' feasibility and gain insights into the potential effectiveness. Methods The REVIVER study involves a mixed methods design, including (1) interviews till data saturation with cancer survivors who completed the interventions as well as with all involved medical professionals, (2) reviews of nurses reports and (3) a single-group, pre-post evaluation among cancer survivors. Eligible survivors are survivors of childhood, adolescent and young adult-onset cancer who are referred to one of the interventions, in complete remission of cancer, 16-44 years old at enrolment, completed treatment at least 5 years ago and have access to a device with Internet options. We will assess feasibility in terms of demand, adherence, acceptability, practicality and integration/implementation. Health-related quality of life, as primary outcome of the potential effectiveness evaluation, will be assessed at three different time points: prior to the intervention; immediately following the intervention and 6 months post-intervention. Secondary outcome measures include changes in level of fatigue, self-efficacy, self-management and lifestyle. Discussion This is the first study to evaluate the feasibility and potential effectiveness of eHealth nurse-led interventions elaborating on person-centred care, using cognitive behavioural therapy and/or motivational interviewing techniques as an innovative and promising approach for providing CAYA cancer survivorship care. If the interventions prove to be feasible and potential effective, a randomized controlled trial will be conducted to test the (cost)-effectiveness.

中文翻译：

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护士主导的儿童、青少年和年轻成人癌症幸存者 (REVIVER) 的视频指导干预：混合方法可行性研究方案。

背景 成功的癌症治疗可导致癌症幸存者倾向于增加终生不良健康影响的风险。因此，早期发现和治疗晚期影响或保持幸存者健康的高质量癌症幸存者护理至关重要。然而，这种护理也需要具有可持续性和成本效益。我们为儿童期、青少年期和青年期癌症的幸存者开发了三种不同的屏幕到屏幕的护士主导的电子健康干预措施，统称为 REVIVER 干预措施。这些干预措施以基于认知行为治疗模块和/或动机性访谈技术的内容详细阐述以人为本的护理原则，旨在授权和指导幸存者改善（1）癌症相关疲劳症状，(2) 自我效能和自我管理或 (3) 生活方式。通过 REVIVER 研究，我们旨在评估干预措施的可行性并深入了解潜在的有效性。方法 REVIVER 研究涉及混合方法设计，包括（1）与完成干预的癌症幸存者以及所有相关医疗专业人员进行访谈直至数据饱和，（2）护士报告的审查和（3）单组，癌症幸存者的事前评估。符合条件的幸存者是儿童、青少年和年轻成人发病癌症的幸存者，他们被转诊至其中一种干预措施，癌症完全缓解，入组时 16-44 岁，至少 5 年前完成治疗，并且可以使用设备与互联网选项。我们将根据需求、依从性、可接受性来评估可行性，实用性和集成/实施。作为潜在有效性评估的主要结果，健康相关的生活质量将在三个不同的时间点进行评估：干预前；干预后立即和干预后 6 个月。次要结果测量包括疲劳程度、自我效能、自我管理和生活方式的变化。讨论 这是第一项评估 eHealth 护士主导的干预措施的可行性和潜在有效性的研究，该干预措施详细阐述了以人为本的护理，使用认知行为疗法和/或动机性访谈技术作为提供 CAYA 癌症生存护理的创新和有前途的方法。如果干预措施被证明是可行和潜在有效的，