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Synthesis of Phenanthridinones by Palladium-Catalyzed Cyclization of N-Aryl-2-aminopyridines with 2-Iodobenzoic Acids in Water
Synlett ( IF 1.7 ) Pub Date : 2019-12-16 , DOI: 10.1055/s-0039-1691538
Xiaojuan Ding 1 , Lei Zhang 1 , Yiyang Mao 1 , Binsen Rong 1 , Ning Zhu 1 , Jindian Duan 1 , Kai Guo 1, 2
Affiliation  

The first Pd-catalyzed cyclization of N-aryl-2-aminopyridines with 2-iodobenzoic acids for the synthesis of phenanthridinones through C–H bond activation under very low catalyst loadings (down to 0.1 mol% Pd) in water is reported. This protocol features a broad substrate scope and provides easy efficient access to various phenanthridinones.

中文翻译:

N-Aryl-2-氨基吡啶与2-碘苯甲酸在水中钯催化环化合成菲啶酮

据报道,首次在 Pd 催化下将 N-芳基-2-氨基吡啶与 2-碘苯甲酸环化,通过 C-H 键活化在水中极低的催化剂负载量(低至 0.1 mol% Pd)合成菲啶酮。该协议具有广泛的底物范围,并提供对各种菲啶酮的轻松有效访问。
更新日期:2019-12-16
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