Synthesis of Phenanthridinones by Palladium-Catalyzed Cyclization of N-Aryl-2-aminopyridines with 2-Iodobenzoic Acids in Water,Synlett

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Synthesis of Phenanthridinones by Palladium-Catalyzed Cyclization of N-Aryl-2-aminopyridines with 2-Iodobenzoic Acids in Water
Synlett ( IF 1.7 ) Pub Date : 2019-12-16 , DOI: 10.1055/s-0039-1691538
Xiaojuan Ding ₁ , Lei Zhang ₁ , Yiyang Mao ₁ , Binsen Rong ₁ , Ning Zhu ₁ , Jindian Duan ₁ , Kai Guo _{1,

2}

Affiliation

The first Pd-catalyzed cyclization of N-aryl-2-aminopyridines with 2-iodobenzoic acids for the synthesis of phenanthridinones through C–H bond activation under very low catalyst loadings (down to 0.1 mol% Pd) in water is reported. This protocol features a broad substrate scope and provides easy efficient access to various phenanthridinones.

中文翻译：

N-Aryl-2-氨基吡啶与2-碘苯甲酸在水中钯催化环化合成菲啶酮

据报道，首次在 Pd 催化下将 N-芳基-2-氨基吡啶与 2-碘苯甲酸环化，通过 C-H 键活化在水中极低的催化剂负载量（低至 0.1 mol% Pd）合成菲啶酮。该协议具有广泛的底物范围，并提供对各种菲啶酮的轻松有效访问。

更新日期：2019-12-16

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