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Therapeutic Targeting of mTORC2 in mTORopathies.
Neuron ( IF 14.7 ) Pub Date : 2019-12-18 , DOI: 10.1016/j.neuron.2019.11.026
Brianne Dentel 1 , Christine Ochoa Escamilla 1 , Peter T Tsai 1
Affiliation  

Dysregulated mTOR contributes to neurodevelopmental dysfunction. A new study (Chen et al., 2019) demonstrates that suppression of mTORC2, not mTORC1, ameliorates survival, seizures, and abnormal behaviors in a Pten mutant model, highlighting mTORC2 as a potential therapeutic target in mTORopathies.

中文翻译:

在mTORopathies中靶向治疗mTORC2。

mTOR失调导致神经发育功能障碍。一项新研究(Chen et al。,2019)表明,抑制mTORC2而非mTORC1可以改善Pten突变体模型中的生存​​,癫痫发作和异常行为,突出显示mTORC2作为mTOR病的潜在治疗靶标。
更新日期:2019-12-19
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