Memories of positive experiences link places, events, and reward outcomes. These memories recruit interactions between the hippocampus and nucleus accumbens (NAc). Both dorsal and ventral hippocampus (dH and vH) project to the NAc, but it remains unknown whether dH and vH act in concert or separately to engage NAc representations related to space and reward. We recorded simultaneously from the dH, vH, and NAc of rats during an appetitive spatial task and focused on hippocampal sharp-wave ripples (SWRs) to identify times of memory reactivation across brain regions. Here, we show that dH and vH awake SWRs occur asynchronously and activate distinct and opposing patterns of NAc spiking. Only NAc neurons activated during dH SWRs were tuned to task- and reward-related information. These temporally and anatomically separable hippocampal-NAc interactions point to distinct channels of mnemonic processing in the NAc, with the dH-NAc channel specialized for spatial task and reward information. VIDEO ABSTRACT.

中文翻译：

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背侧和腹侧海马尖波波纹激活不同的伏隔核网络。

积极体验的记忆将地点、事件和奖励结果联系起来。这些记忆会招募海马体和伏隔核 (NAc) 之间的相互作用。背侧和腹侧海马（dH 和 vH）都投射到 NAc，但尚不清楚 dH 和 vH 是协同作用还是单独作用以参与与空间和奖励相关的 NAc 表示。我们在食欲空间任务期间同时记录大鼠的 dH、vH 和 NAc，并专注于海马尖波波纹 (SWR)，以识别跨大脑区域的记忆重新激活时间。在这里，我们展示了 dH 和 vH 清醒 SWR 异步发生并激活不同且相反的 NAc 尖峰模式。只有在 dH SWR 期间激活的 NAc 神经元被调整为与任务和奖励相关的信息。这些时间和解剖学上可分离的海马-NAc 相互作用指向 NAc 中不同的记忆处理通道，其中 dH-NAc 通道专门用于空间任务和奖励信息。视频摘要。