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Efficient Synthesis of Dibenzazepine Lactams via a Sequential Pd-Catalyzed Amination and Aldol Condensation Reaction
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2019-12-18 , DOI: 10.1016/j.tetlet.2019.151536
Ha-Jeong Song , Eunyoung Yoon , Jung-Nyoung Heo

A simple and efficient reaction was developed for the synthesis of dibenzazepine lactam derivatives. The core 7-membered azepine ring was formed by a stepwise sequence involving a palladium-catalyzed amination and an aldol condensation.



中文翻译:

通过顺序的Pd催化胺化和Aldol缩合反应有效合成Dibenzazepine内酰胺

开发了一种简单而有效的反应来合成二苯并ze庚内酰胺衍生物。核心的7元氮杂环庚烷环是通过逐步步骤形成的,该步骤涉及钯催化的胺化反应和醛醇缩合反应。

更新日期:2019-12-19
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