Brachial-ankle pulse wave velocity in healthy Japanese adolescents: reference values for the assessment of arterial stiffness and cardiovascular risk profiles,Hypertension Research

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Brachial-ankle pulse wave velocity in healthy Japanese adolescents: reference values for the assessment of arterial stiffness and cardiovascular risk profiles
Hypertension Research ( IF 4.3 ) Pub Date : 2019-12-18 , DOI: 10.1038/s41440-019-0370-z
Yukiko Sougawa ₁ , Nobuyuki Miyai ₁ , Miyoko Utsumi ₁ , Kazuhisa Miyashita ₂ , Shintaro Takeda ₂ , Mikio Arita ₃

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Brachial-ankle pulse wave velocity (baPWV) has been used as a simple and convenient method of evaluating arterial stiffness and is considered useful for screening subclinical vascular damage in primary care settings and in large populations. The aim of this study was to determine the reference values of baPWV in adolescents based on age and sex to evaluate and classify vascular abnormalities in this age population. Noninvasive baPWV measurements using an oscillometric device were carried out in 5936 participants aged 12–18 years who had no history of syndromic obesity, hypertension, dyslipidemia, diabetes mellitus, or renal disease. Of these, we extracted data from 4524 healthy adolescents free from atherosclerotic risk factors and constructed sex-specific reference percentiles normalized to age using the LMS method. The baPWV increased with age and was significantly higher in males than in females. Multivariate regression analysis demonstrated that age, body mass index, and blood pressure were the major determinants of baPWV for both males and females. Among a sample of 3825 adolescents, including individuals with risk factors, the prevalence of central obesity, raised blood pressure, raised triglycerides, reduced high-density lipoprotein cholesterol, and impaired fasting glycemia significantly increased along with the standardized baPWV z -score level. In addition, there was a graded nature regarding the association between the baPWV z -score and the clustering number of the metabolic syndrome components. These results suggest that the proposed reference values of baPWV could help classify vascular abnormalities of adolescents caused by the presence of risk factors and thereby contribute to determining individuals with cardiovascular risk in this age population.

中文翻译：

健康日本青少年的臂踝脉搏波速度：评估动脉僵硬度和心血管风险的参考值

臂踝脉搏波速度 (baPWV) 已被用作评估动脉僵硬度的一种简单方便的方法，被认为可用于在初级保健机构和大量人群中筛查亚临床血管损伤。本研究的目的是根据年龄和性别确定青少年 baPWV 的参考值，以评估和分类该年龄人群的血管异常。使用示波装置对 5936 名年龄在 12-18 岁之间没有综合征性肥胖、高血压、血脂异常、糖尿病或肾病史的参与者进行了无创 baPWV 测量。其中，我们从 4524 名没有动脉粥样硬化危险因素的健康青少年中提取数据，并使用 LMS 方法构建了针对年龄标准化的性别特异性参考百分位数。baPWV 随年龄增长而增加，男性显着高于女性。多元回归分析表明，年龄、体重指数和血压是男性和女性 baPWV 的主要决定因素。在 3825 名青少年样本中，包括具有危险因素的个体，中心性肥胖、血压升高、甘油三酯升高、高密度脂蛋白胆固醇降低和空腹血糖受损的患病率随着标准化的 baPWV z 分数水平显着增加。此外，baPWV z 分数与代谢综合征成分的聚类数之间的关联存在分级性质。

更新日期：2019-12-18

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