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FeCl3 mediated dimerization of dihydropyrrolo[2,1-a]isoquinolines and chlorination of tetrasubstituted pyrroles.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-01-02 , DOI: 10.1039/c9ob02607j Xue-Fei Jiang 1 , Hao Tan 1 , Hai-Lei Cui 1
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-01-02 , DOI: 10.1039/c9ob02607j Xue-Fei Jiang 1 , Hao Tan 1 , Hai-Lei Cui 1
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We have developed a mild and direct dimerization of dihydropyrrolo[2,1-a]isoquinolines through FeCl3-mediated oxidative homocoupling. A series of dimeric dihydropyrroloisoquinoline derivatives were obtained in acceptable to excellent yields (up to >99%). Attempts to expand this dimerization system to the synthesis of dimeric pyrroles failed and chlorination products were obtained in most cases instead of dimeric pyrroles.
中文翻译：
FeCl3介导二氢吡咯并[2,1-a]异喹啉的二聚和四取代吡咯的氯化。
我们已经开发了通过FeCl3介导的氧化均质偶合的二氢吡咯并[2,1-a]异喹啉的温和直接二聚。以可接受的优异产率（高达> 99％）获得了一系列二聚二氢吡咯并异喹啉衍生物。尝试将该二聚体系扩展至二聚吡咯的合成失败，并且在大多数情况下获得了氯化产物而不是二聚吡咯。
更新日期：2020-02-10
中文翻译：
FeCl3介导二氢吡咯并[2,1-a]异喹啉的二聚和四取代吡咯的氯化。
我们已经开发了通过FeCl3介导的氧化均质偶合的二氢吡咯并[2,1-a]异喹啉的温和直接二聚。以可接受的优异产率（高达> 99％）获得了一系列二聚二氢吡咯并异喹啉衍生物。尝试将该二聚体系扩展至二聚吡咯的合成失败，并且在大多数情况下获得了氯化产物而不是二聚吡咯。
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