The postprandial blood glucose and hormonal responses to isomalto-oligosaccharides (IMO) are unclear. The objective of this study was to compare postprandial glucose, insulin and incretin responses of IMO with dextrose in healthy adults. In trial 1, blood glucose responses to IMO, isomaltose, dextran and maltodextrin were compared with dextrose in n = 12 participants. In trial 2, serial glucose and hormone measurements over 2 h were measured in n = 10 participants. The glycemic effect of IMO was calculated using the Glycemic Glucose Equivalents (GGE) and Relative Glycemic Index (RGI). IMO exhibited a hyperglycemic effect compared to dextrose as indicated by a GGE of 1.35 g and an RGI of 27.0 g. The responses to IMO of both active GLP-1 and GIP were similar to that of dextrose. The paradoxical hyperglycemic response despite robust insulin and incretin secretion requires further investigation.

餐后血糖和激素对异麦芽低聚糖（IMO）的反应尚不清楚。这项研究的目的是比较健康成年人中IMO与葡萄糖对餐后血糖，胰岛素和肠降血糖素的反应。在试验1中，在12例参与者中，比较了对IMO，异麦芽糖，右旋糖酐和麦芽糊精的血糖反应与右旋糖。在试验2中，在n = 10的参与者中测量了超过2小时的连续葡萄糖和激素测量值。IMO的血糖效应是使用血糖当量（GGE）和相对血糖指数（RGI）计算的。与葡萄糖相比，IMO表现出高血糖作用，GGE为1.35 g，RGI为27.0 g。活性GLP-1和GIP对IMO的响应与右旋糖相似。