IP3 receptor turnover is mediated by the ubiquitin ligase RNF170, which is recruited to active IP3 receptors by the erlin1/2 complex. A new study by Wagner et al (Nat Commun, 2019) links four cases of Hereditary Spastic Paraplegia to inactivating mutations in RNF170. This increases the number of examples of mutations to the erlin1/2 complex-RNF170 module underlying neurodegenerative disorders.

中文翻译：

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IP3受体转换与遗传性痉挛性截瘫之间的新兴联系。

IP3受体转换是由泛素连接酶RNF170介导的，该蛋白被erlin1 / 2复合物募集到活性IP3受体上。Wagner等人的一项新研究（Nat Commun，2019年）将4例遗传性痉挛性截瘫患者与RNF170的失活突变联系起来。这增加了潜在的神经退行性疾病的erlin1 / 2复合物-RNF170模块突变的例子。