Psychiatric researchers grapple with concerns that individuals with mental illness may be less likely to appreciate risks of research participation, particularly compared to people not suffering from mental illness. Therefore, empirical studies that directly compare the perspectives of such individuals are needed. In addition, it is important to evaluate perspectives regarding varied types of research protocols, particularly as innovative psychiatric research protocols emerge. In this pilot study, respondents with a mood disorder (n = 25) as well as respondents without a mood disorder (n = 55) were recruited using Amazon's Mechanical Turk (MTurk) platform. These respondents were surveyed regarding four psychiatric research projects (i.e., experimental medication [pill form]; non-invasive magnetic brain stimulation; experimental medication [intravenous infusion]; and implantation of a device in the brain). Regardless of health status, respondents rated the four research protocols as somewhat to highly risky. The brain-device implant protocol was seen as the most risky, while the magnetic brain stimulation project was viewed as "somewhat risky". Respondents, on average and regardless of health status, rated their willingness at or below "somewhat willing." Respondents were least willing to participate in the brain-device implant protocol, whereas they were "somewhat willing" to participate in the magnetic brain stimulation protocol. Trust in medical research was negatively associated with perceived risk of research protocols. Perceived risk was negatively associated with willingness to participate, even when adjusting for potential confounders, suggesting that attunement to risk crosses diagnostic, gender, and ethnic categories, and is more salient to research decision-making than trust in medical research and dispositional optimism. The findings of this study may offer reassurance about the underlying decision-making processes of individuals considering participation in innovative neuroscience studies.

中文翻译：

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感知风险与参与创新精神病学研究方案的意愿呈负相关。


精神病学研究人员担心患有精神疾病的人可能不太可能意识到参与研究的风险，特别是与未患有精神疾病的人相比。因此，需要直接比较这些人的观点的实证研究。此外，评估有关不同类型研究方案的观点也很重要，特别是随着创新精神病学研究方案的出现。在这项试点研究中，使用亚马逊的 Mechanical Turk (MTurk) 平台招募了患有情绪障碍的受访者 (n = 25) 以及没有情绪障碍的受访者 (n = 55)。这些受访者接受了关于四个精神病学研究项目的调查（即实验药物[药丸形式]；非侵入性磁脑刺激；实验药物[静脉输注]；以及在大脑中植入装置）。无论健康状况如何，受访者都认为这四种研究方案风险较高。大脑设备植入方案被认为风险最大，而磁脑刺激项目被认为“有一定风险”。平均而言，无论健康状况如何，受访者将自己的意愿评为“有些愿意”或低于“有些愿意”。受访者最不愿意参与大脑设备植入方案，而他们“有点愿意”参与磁脑刺激方案。对医学研究的信任与研究方案的感知风险呈负相关。 即使在调整潜在的混杂因素时，感知风险与参与意愿呈负相关，这表明对风险的协调跨越诊断、性别和种族类别，并且对研究决策的影响比对医学研究的信任和性格乐观更为重要。这项研究的结果可能会为考虑参与创新神经科学研究的个人的基本决策过程提供保证。