In a case-control study, Katie Lewis and colleagues investigated the association between polygenic risk scores for sleep traits and bipolar disorder subtypes I and II. Analysis included UK data for 3404 individuals with bipolar I disorder, 1268 individuals with bipolar II disorder, and 5714 control participants. Compared with controls, the polygenic risk score for insomnia was associated with risk of bipolar II disorder (relative risk 1·14 [95% CI 1·07–1·21]; p=8·26×10 ⁻⁵), while the polygenic risk score for sleep duration was associated with risk of bipolar I disorder (1·10 [1·06–1·15]; p=1·13×10 ⁻⁵). These associations were replicated in an independent Swedish cohort. Polygenic risk scores for daytime sleepiness and chronotype were not associated with risk of the two bipolar disorder subtypes.

中文翻译：

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研究综述。

在病例对照研究中，凯蒂·刘易斯（Katie Lewis）及其同事研究了睡眠性状的多基因风险评分与I型和II型双相情感障碍之间的关联。分析包括英国的3404例双相I型障碍患者，1268例双相II型障碍患者和5714对照参与者的英国数据。与对照组相比，失眠的多基因风险评分与双相情感障碍II的风险相关（相对风险1·14 [95％CI 1·07-1·21]； p = 8·26×10 ^-5），而睡眠时间的多基因风险评分与双相性I型障碍的风险相关（1·10 [1·06-1·15]； p = 1·13×10 ^-5）。这些关联在一个独立的瑞典队列中被复制。白天嗜睡和表型的多基因风险评分与两种双相情感障碍亚型的风险均不相关。