Background

Previous studies found conflicting results about whether hidradenitis suppurativa (HS) is associated with depression or anxiety.

Objectives

To determine the relationship of HS with depression and anxiety.

Methods

A systematic review was performed of published observational studies in MEDLINE, PubMed, Embase, Global Resource for Eczema Trials (GREAT), Latin American and Caribbean Health Sciences Literature (LILACS), Cochrane, Scopus, and PsychInfo that analyzed depression or anxiety in HS. Two reviewers performed title/abstract review and data extraction. Meta-analysis was performed with random-effects weighting.

Results

Thirty-eight studies met inclusion criteria; 27 had sufficient data for meta-analysis. The prevalences of depression (26.5% vs 6.6%) and anxiety (18.1% vs 7.1%) were higher in persons with versus without HS. Patients with HS had higher odds of depression in 12 of 13 studies and pooled analysis (odds ratio, 2.54; 95% confidence interval, 2.15-3.01), and anxiety in 6 of 6 studies and pooled analysis (odds ratio, 2.00; 95% confidence interval, 1.66-2.42). Similar results were found in sensitivity analyses for different methods of HS diagnosis (physician diagnosed and chart review) and control groups (healthy and dermatologic control individuals). HS was associated with higher antidepressant and anxiolytic use and with suicidality, but not mean depression and anxiety scale scores.

Limitations

Individual-level data were unavailable.

Conclusions

Patients with HS have higher odds of depression, anxiety, and suicidality.

中文翻译：

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化脓性汗腺炎，抑郁症，焦虑症和自杀倾向之间的关联：系统评价和荟萃分析。

背景

先前的研究发现有关化脓性汗腺炎（HS）与抑郁症或焦虑症相关的结果相互矛盾。

目标

确定HS与抑郁和焦虑的关系。

方法

对MEDLINE，PubMed，Embase，全球湿疹试验资源（GREAT），拉丁美洲和加勒比海健康科学文献（LILACS），Cochrane，Scopus和PsychInfo中已发表的观察性研究进行了系统的综述，这些研究分析了HS中的抑郁症或焦虑症。两名审稿人进行了标题/摘要审阅和数据提取。荟萃分析以随机效应加权进行。

结果

38项研究符合纳入标准；27个具有足够的数据进行荟萃分析。有和没有HS的人中，抑郁症（26.5％vs. 6.6％）和焦虑症（18.1％vs 7.1％）的患病率更高。HS患者在13项研究和汇总分析中的12项中有较低的抑郁几率（几率2.54; 95％置信区间为2.15-3.01），6项研究和汇总分析中有6例焦虑率较高（几率2.00; 95％置信区间1.66-2.42）。在针对HS诊断的不同方法（医生诊断和图表审查）和对照组（健康和皮肤病控制人员）的敏感性分析中发现了相似的结果。HS与较高的抗抑郁和抗焦虑药使用以及自杀倾向有关，但并不意味着抑郁和焦虑量表评分。

局限性

个人级别的数据不可用。

结论

HS患者的抑郁，焦虑和自杀倾向的几率更高。