It is known that electrical stimulation of the external lateral parabrachial nucleus (NLPBe) can sustain concurrent taste and place learning. Place preferences can be learned through different procedures. Previous studies demonstrated that electrical stimulation of the PBNLe can generate aversive and preference place learning using concurrent procedures. In the concurrent procedure, the animals can move freely in the maze, and intracranial electrical stimulation is associated with their voluntary stay in one of the two maze compartments. However, the rewarding properties of most stimuli, whether natural or drugs of abuse, have usually been investigated using the sequential procedure, in which animals are confined while receiving the unconditioned stimulus and then undergo a choice test without stimulation in a later phase. This study examined whether this stimulation can sustain place preference learning in sequential tasks. Results demonstrated that place preferences can also be induced by the electrical stimulation of the NLBe using sequential procedures. These findings suggest that the NLPBe may form part of a brain reward axis that shares certain characteristics with those observed in the processing of natural rewarding agents and especially of drugs of abuse.

中文翻译：

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在顺序学习任务中放置由外侧外侧臂旁臂旁核的电刺激引起的偏好：放置由NLPBe刺激引起的偏好。

已知对外侧臂外侧臂旁核（NLPBe）的电刺激可维持同时的味觉和位置学习。可以通过不同的程序来学习位置偏好。先前的研究表明，PBNLe的电刺激可通过并发程序产生厌恶和偏爱场所学习。在同时进行的过程中，动物可以在迷宫中自由移动，颅内电刺激与它们自愿留在两个迷宫隔室之一有关。但是，通常使用顺序程序来研究大多数刺激物的奖励性质，无论是自然刺激物还是滥用药物，在这种过程中，动物在受到无条件刺激的同时被限制，然后在随后的阶段接受无刺激的选择测试。这项研究检查了这种刺激是否可以维持顺序任务中的位置偏好学习。结果表明，使用顺序程序也可以通过NLBe的电刺激来诱发位置偏好。这些发现表明，NLPBe可能构成大脑奖励轴的一部分，该大脑奖励轴的某些特征与天然奖励剂尤其是滥用药物的加工过程中观察到的特征相同。