Engineering a Novel 3D Printed Vascularized Tissue Model for Investigating Breast Cancer Metastasis to Bone.,Advanced Healthcare Materials

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Engineering a Novel 3D Printed Vascularized Tissue Model for Investigating Breast Cancer Metastasis to Bone.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2019-12-17 , DOI: 10.1002/adhm.201900924
Haitao Cui ₁ , Timothy Esworthy ₁ , Xuan Zhou ₁ , Sung Yun Hann ₁ , Robert I Glazer ₂ , Rong Li ₃ , Lijie Grace Zhang _{1,

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Affiliation

Cancer metastases are a challenge for cancer treatment due to their organ specificity and pathophysiological complexity. Engineering 3D in vitro models capable of replicating native cancer dissemination can significantly improve the understanding of cancer biology and can help to guide the development of more effective treatments. In order to better mimic the behavior of native cancer, a triculture metastatic model is created using a stereolithography printing technique with optimized inks for investigating the invasion of breast cancer (BrCa) cells into vascularized bone tissue. The printed system allows to study transendothelial migration and the colony‐forming behavior of metastatic BrCa cells. The key steps of BrCa cell progression including expansion, migration, and colonization are continuously monitored and the interactions between cancer cells, vascular cells, and bone cells are systematically investigated. The study results demonstrate that the 3D printed tissue construct by incorporating multiple cells and various favorable ink matrices provides a suitable model to study the interaction between these cells in a complex vascular microenvironment. As such, the 3D printed tricultured model may serve as a valuable tool for studying metastatic breast cancer progression in bone.

中文翻译：

设计用于研究乳腺癌骨转移的新型 3D 打印血管组织模型。

由于其器官特异性和病理生理学复杂性，癌症转移是癌症治疗的一个挑战。能够复制天然癌症传播的工程 3D 体外模型可以显着提高对癌症生物学的理解，并有助于指导更有效治疗方法的开发。为了更好地模拟天然癌症的行为，使用立体光刻印刷技术和优化油墨创建了三培养转移模型，用于研究乳腺癌 (BrCa) 细胞侵入血管化骨组织。打印系统可以研究转移性 BrCa 细胞的跨内皮迁移和集落形成行为。持续监测 BrCa 细胞进展的关键步骤，包括扩张、迁移和定植，并系统地研究癌细胞、血管细胞和骨细胞之间的相互作用。研究结果表明，通过整合多个细胞和各种有利的墨水基质而构建的 3D 打印组织结构，为研究复杂血管微环境中这些细胞之间的相互作用提供了合适的模型。因此，3D 打印的三培养模型可以作为研究骨转移性乳腺癌进展的有价值的工具。

更新日期：2019-12-17

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