BACKGROUND Articular osteochondrosis follows a dynamic development pattern. Lesions arise, in incidence peaks compatible with failure of cartilage canal vessels during incorporation into bone, and can also resolve. Lesions that resolve before examination at a single time point will constitute false-negative diagnoses. The aim of the study was to identify physeal osteochondrosis lesions in pigs and monitor their development by computed tomography (CT), to determine if they follow a similar dynamic development pattern to articular osteochondrosis. RESULTS Thirteen physes were evaluated bilaterally in up to eight biweekly CT scans from 18 male Landrace pigs age 70-180 days (total: 112 scans), generating 2912 scores. There were 1754 (60%) lesion-negative scores and 1158 (40%) lesion-positive scores. Positive scores comprised 138 lesions present at the start and 235 lesions that developed during the study, from 4 to 32 lesions per physis (median: 15 lesions). There were 1-2 peaks in the incidence curves for 12/13 examined physes, the exception being the proximal humerus. Positive scores also included 785 times that lesions persisted, from 1.3-4.8 examination intervals per lesion (median: 2.8 intervals). Negative scores included 190 times that lesions resolved, from 19 to 100% of lesions per physis (median: 65%). Lesions resolved by filling with bone from marginal sclerosis and reparative ossification centres. In the distal scapula and distal fibula, perichondrial new bone formation occurred that led to permanent enlargement of physeal regions. Angular limb deformity was not identified in any pig. CONCLUSIONS Physeal osteochondrosis followed a similar dynamic development pattern to articular osteochondrosis. There were peaks in the incidence curves, compatible with failure of vessels during incorporation into bone. In some physes, osteochondrosis led to permanent enlargement, potentially relevant for decubital ulcers. The relationship between physeal osteochondrosis and angular limb deformity must be examined further in pigs over 6 months old in future.

中文翻译：

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猪的骨软骨病的计算机断层摄影发展。

背景技术关节骨软骨病遵循动态发展模式。病变出现在与骨结合的过程中与软骨管衰竭相适应的入射峰中，并且也可以消退。在单个时间点检查前解决的病变将构成假阴性诊断。该研究的目的是识别猪的骨软骨病，并通过计算机断层扫描（CT）监测其发展，以确定它们是否遵循与关节骨软骨病类似的动态发展模式。结果在18头70-180天的雄性长白猪中，共进行了八次双周CT扫描，共进行了13次双侧活检（共112次扫描），得分为2912。病变阴性评分为1754（60％），病变阳性评分为1158（40％）。阳性评分包括研究开始时出现的138个病变和研究过程中出现的235个病变，每个生理学从4到32个病变（中位数：15个病变）。对于12/13个检查的植体，入射曲线中有1-2个峰，除了肱骨近端。阳性评分还包括病变持续的785次，每个病变1.3-4.8个检查间隔（中位数：2.8个间隔）。阴性评分包括病变消融的190倍，每个物理病变的19％到100％（中位数：65％）。通过填充边缘硬化和修复性骨化中心的骨骼来解决病变。在肩骨远端和腓骨远端，发生了软骨膜新骨形成，导致永久性的骨赘区域扩大。在任何猪中都没有发现角状肢畸形。结论物理性骨软骨病的动态发展模式与关节骨软骨病类似。在入射曲线中有峰值，与掺入骨中的血管破裂相适应。在某些植物中，骨软骨病导致永久性肿大，可能与褥疮有关。未来6个月以上的猪必须进一步检查骨赘软骨病和四肢成角畸形之间的关系。