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Prevalence and incidence of non-gout crystal arthropathy in southern Sweden
Arthritis Research & Therapy ( IF 4.4 ) Pub Date : 2019-12-17 , DOI: 10.1186/s13075-019-2077-6
Mohaned Hameed , Aleksandra Turkiewicz , Martin Englund , Lennart Jacobsson , Meliha C. Kapetanovic

To estimate the prevalence and incidence of non-gout crystal arthropathy in relation to socioeconomic factors in southern Sweden. All patients (age ≥ 18 years) with at least one visit to a physician with the diagnosis of interest in the Skåne region (population of 1.3 million) in 1998–2014 were identified. Non-gout crystal arthropathy (ICD-10 codes M11.0–M11.9) was subclassified in four different groups: calcium pyrophosphate crystal deposition related arthropathy (CPPD), unspecified non-gout arthropathies, chondrocalcinosis, and hydroxyapatite crystal deposition disease. The crude and age-adjusted point prevalence on December 31, 2014, and the cumulative incidence during 2014 were calculated for all non-gout crystal arthropathies, CPPD, and other unspecified non-gout arthropathies overall and in relation to occupation, income, and level of education. The crude 2014 point prevalence (95% CI) and 2014 cumulative incidence (95% CI) of all non-gout crystal arthropathies were 0.23% (0.23–0.24) and 21.5 (19–25) cases/100,000 persons. Mean age (range) among all prevalent cases in 2014 was 71 (20–102) years and 56% were males. The point prevalence and cumulative incidence of CPPD were 0.09% (0.08–0.09) and 8 (7–10)/100,000 persons, respectively. The corresponding data for unspecified non-gout crystal deposition disease was 0.16% (0.16–0.17) and 15.6 (13–18)/100,000 persons, respectively. The prevalence and incidence of CPPD and unspecified non-gout crystal arthropathies were slightly higher in men and increased with age irrespective of gender. Unspecified non-gout crystal arthropathy but not CPPD was less prevalent in persons with ≥ 15 years of education, whereas there were no clear associations with occupation and income. The prevalence of all diagnosed non-gout crystal arthropathies was 0.23%, thus considerably less prevalent than gout in southern Sweden. CPPD and other unspecified non-gout crystal arthropathies are the predominant diagnoses, increasing with age and in men. With the exception for unspecified non-gout crystal arthropathies being inversely correlated to a higher level of education, no convincing association with the socioeconomic factors was found.

中文翻译:

瑞典南部非痛风性晶体关节炎的患病率和发病率

评估与瑞典南部社会经济因素相关的非痛风性晶体关节炎的患病率和发病率。确定了1998-2014年斯科讷地区(人口130万)中至少有一次就诊且被诊断为有兴趣的医师的所有患者(年龄≥18岁)。非痛风性晶体关节炎(ICD-10代码为M11.0–M11.9)分为四个不同的组:焦磷酸钙晶体沉积相关性关节炎(CPPD),未指明的非痛风性关节炎,软骨钙化病和羟基磷灰石晶体沉积性疾病。针对所有非痛风性晶体关节病,CPPD和其他未指明的非痛风性关节病,整体上以及与职业,收入,和教育水平。2014年,所有非痛风性晶体关节病的原始2014年患病率(95%CI)和2014年累积发生率(95%CI)分别为0.23%(0.23-0.24)和21.5(19-25)例/ 100,000人。2014年所有流行病例的平均年龄(范围)为71(20-102)岁,男性为56%。CPPD的点流行率和累积发生率分别为0.09%(0.08-0.09)和8(7-10)/ 100,000人。未指定的非痛风性晶体沉积疾病的相应数据分别为0.16%(0.16-0.17)和15.6(13-18)/ 100,000人。男性的CPPD和未指明的非痛风性晶体关节病的患病率和发病率略高,并且随年龄增长而增加,而与性别无关。受过教育的15岁以上的人群,未明确的非痛风性结晶性关节病而非CPPD的患病率较低,而与职业和收入之间没有明确的关联。所有诊断出的非痛风性晶体关节病的患病率为0.23%,因此比瑞典南部的痛风病患病率低得多。CPPD和其他未指定的非痛风性晶体关节病是主要的诊断,随年龄和男性而增加。除了未明确说明的非痛风性晶体关节病与较高的教育水平成反比外,没有发现令人信服的与社会经济因素的联系。
更新日期:2019-12-18
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