A vast growing problem in orthopaedic medicine is the increase of clinical cases with antibiotic resistant pathogenic microbes, which is predicted to cause higher mortality than all cancers combined by 2050. Bone infectious diseases limit the healing ability of tissues and increase the risk of future injuries due to pathologic tissue remodelling. The traditional treatment for bone infections has several drawbacks and limitations, such as lengthy antibiotic treatment, extensive surgical interventions, and removal of orthopaedic implants and/or prosthesis, all of these resulting in long-term rehabilitation. This is a huge burden to the public health system resulting in increased healthcare costs. Current technologies e.g. co-delivery systems, where antibacterial and osteoinductive agents are delivered encounter challenges such as site-specific delivery, sustained and prolonged release, and biocompatibility. In this review, these aspects are highlighted to promote the invention of the next generation biomaterials to prevent and/or treat bone infections and promote tissue regeneration.

中文翻译：

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骨科应用中双重功能的抗菌和骨诱导生物材料的研究进展。

整形外科医学中一个日益严重的问题是，抗生素耐药性致病微生物的临床病例增加，预计到2050年其死亡率将高于所有癌症。骨传染性疾病限制了组织的愈合能力，并增加了未来因损伤而受伤的风险。病理组织重塑。骨感染的传统治疗方法有许多缺点和局限性，例如冗长的抗生素治疗，广泛的外科手术以及骨科植入物和/或假体的去除，所有这些都导致长期康复。这给公共卫生系统带来了沉重负担，导致医疗费用增加。目前的技术，例如共同交付系统，在交付抗菌和骨诱导剂的地方遇到挑战，例如特定部位的交付，持续和长期释放以及生物相容性。在这篇综述中，强调了这些方面以促进下一代生物材料的发明，以预防和/或治疗骨感染并促进组织再生。