AIMS To assess whether parental alcohol use disorder (AUD) is associated with higher risks of living in a non-intact family and assess whether non-intact family structure is associated with higher risks of AUD in the offspring. DESIGN Prospective cohort study. SETTING Danish nationwide registries. PARTICIPANTS 9,948 parental AUD offspring and 98,136 reference offspring from the Danish population. MEASUREMENTS Family structure assessed at birth and at each birthday until age 15 as intact or non-intact (with mother only, father only or neither parent). Years lived in an intact family defined as total number of years lived with both parents from birth until 15th birthday. AUD defined as registration in medical, treatment and cause of death registries. Data was analyzed by Cox regression. FINDINGS At birth, 30.9% (95% CI = 29.1-32.6) of parental AUD offspring and 10.7% (95% CI = 10.3-11.0) of reference offspring lived in a non-intact family. At age 15, the numbers were 84.6% (95% CI = 83.9-85.3) and 38.4% (95% CI = 38.1-38.7). Parental AUD was associated with a higher risk of offspring AUD (HR = 1.88, 95% CI = 1.74-2.02). Offspring were at lower risk of AUD if they lived 15 years in an intact family compared with offspring who never lived in an intact family (HR = 0.67, 95% CI = 0.52-0.87 for those with parental AUD, and HR = 0.53, 95% CI = 0.48-0.59 for those whose parents did not have AUD). Findings were inconclusive as to whether or not an association was present between family structure and AUD among offspring with parental AUD and reference offspring. CONCLUSIONS The prevalence of non-intact family structure appears to be higher in offspring of parents with alcohol use disorder (AUD) than among offspring from the general population. Parental AUD appears to be associated with increased risk of offspring AUD, and non-intact family structure appears to be associated with increased risk of offspring AUD regardless of parental AUD.

中文翻译：

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家庭结构和酒精使用障碍：一项基于登记册的队列研究，对有和没有父母酒精使用障碍的后代进行

目的 评估父母酒精使用障碍 (AUD) 是否与生活在不完整家庭中的较高风险相关，并评估不完整的家庭结构是否与后代较高的 AUD 风险相关。设计前瞻性队列研究。设置丹麦全国注册。参与者 来自丹麦人口的 9,948 名父母 AUD 后代和 98,136 名参考后代。测量 家庭结构在出生时和直到 15 岁之前的每个生日评估为完整或不完整（只有母亲，只有父亲或没有父母）。在完整家庭中生活的年数定义为从出生到 15 岁生日与父母双方共同生活的总年数。AUD 定义为在医疗、治疗和死因登记处登记。通过Cox回归分析数据。结果 出生时为 30.9%（95% CI = 29.1-32。6) 的父母 AUD 后代和 10.7% (95% CI = 10.3-11.0) 的参考后代生活在一个不完整的家庭中。在 15 岁时，这些数字分别为 84.6% (95% CI = 83.9-85.3) 和 38.4% (95% CI = 38.1-38.7)。父母澳元与后代澳元风险较高相关（HR = 1.88，95% CI = 1.74-2.02）。与从未在完整家庭中生活过的后代相比，如果他们在完整家庭中生活了 15 年，后代患 AUD 的风险较低（对于父母为 AUD 的人，HR = 0.67，95% CI = 0.52-0.87，HR = 0.53, 95对于父母没有澳元的人，% CI = 0.48-0.59）。对于父母 AUD 和参考后代的家庭结构与 AUD 之间是否存在关联，研究结果尚无定论。结论 患有酒精使用障碍 (AUD) 的父母的后代中，家庭结构不完整的患病率似乎高于一般人群的后代。父母 AUD 似乎与后代 AUD 的风险增加有关，而不完整的家庭结构似乎与后代 AUD 的风险增加有关，而与父母 AUD 无关。