Accumulation at tumor tissue without any damage to healthy normal tissues is an ultimate goal in cancer therapy. Despite many efforts in the field of cancer therapy, this disease remains as the major reason of mortality all over the world. Gene therapy has introduced great opportunity to fight against cancer disease. It should be noted that still some obstacles limit clinical application of gene delivery approach, which have to be overcome for efficient transportation of therapeutic gene to the site of action. In this regard, carbon nanomaterials and their unique physical and chemical properties such as their capability of DNA protection have attracted much attention in the field of nanomedicine and non-viral carriers for therapeutic genes. Although, negligible solubility of carbon nanomaterials in biological environments has limited their biomedical application but their structural characteristics facilitate their chemical modifications thereby overcoming their solubility problem. Moreover, hybridization of modified carbon materials with different polymers provides more biocompatible and capable systems for gene delivery purposes. In the current review, we summarized hybrid carbon-based materials as non-viral carriers for gene delivery.

中文翻译：

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用于癌症治疗中基因传递的基于碳的混合材料。

在肿瘤组织中积累而不损害健康正常组织是癌症治疗的最终目标。尽管在癌症治疗领域进行了许多努力，但该疾病仍然是全世界死亡的主要原因。基因疗法为抗击癌症疾病带来了巨大的机会。应该注意的是，仍然有一些障碍限制了基因递送方法的临床应用，必须将这些障碍克服才能有效地将治疗性基因转运到作用部位。在这方面，碳纳米材料及其独特的物理和化学特性，例如其DNA保护的能力，在用于治疗基因的纳米药物和非病毒载体领域引起了广泛的关注。虽然，碳纳米材料在生物环境中的微不足道的溶解度限制了它们在生物医学上的应用，但是它们的结构特征促进了它们的化学修饰，从而克服了它们的溶解性问题。而且，改性碳材料与不同聚合物的杂交为基因递送目的提供了更多的生物相容性和能力强的系统。在当前的审查中，我们总结了基于碳的混合材料作为基因传递的非病毒载体。