Skin tissue regeneration scaffolds represent a promising field of research focused on formulation and optimization of cost-effective extracellular matrix based on natural polymers. Sodium carboxymethylcellulose is one of the most widely studied and least expensive natural polymers for fabricating film formulations aiding in skin tissue regeneration process the following damage, but its hydrophilicity contributes to its failure to prevent loss of excessive moisture from wound, low adsorb-ability, less mechanical strength, and rapid erosion. This study aims to develop a surfactant modified sodium carboxymethylcellulose-based films addressing the needs for skin wound healing applications. Sodium carboxymethylcellulose films were developed with varying concentrations of tween 80 in the range of 0.05 to 0.5% w/w and subjected to various physicochemical characterization tests like adsorption, moisture uptake, erosion, water vapor transmission, and water vapor permeability rate, vibrational, thermal and morphological analysis. The results indicated that the formulation containing 0.3% w/w of tween 80 was able to form films with a significant-good adsorb-ability, reduced percent erosion and high tensile strength with the formation of “folds” in the film surface. The vibrational and thermal analysis revealed fluidization of hydrophilic as well as hydrophobic domains which was attributed to the development of new “bonding” between the polymer and surfactant and/or plasticizer moieties in the formulation which though didn’t affect the transition temperature but significantly reduced the energy to induce transition which is envisaged to increase the elasticity of the film. This optimized combination of polymer and tween 80 may play an effective role in hastening skin regeneration process following damage. Sodium carboxymethylcellulose films with added 0.3% w/w tween 80 represent an ideal combination for the fabrication of sodium carboxymethylcellulose.

皮肤组织再生支架代表着一个有前途的研究领域，致力于基于天然聚合物的成本有效的细胞外基质的配制和优化。羧甲基纤维素钠是制备膜制剂的最广泛研究和最便宜的天然聚合物之一，可用于皮肤组织再生过程，具有以下破坏性，但其亲水性导致其无法防止伤口流失过多的水分，低吸附性，低吸收性机械强度大，腐蚀迅速。这项研究旨在开发一种表面活性剂改性的羧甲基纤维素钠基薄膜，以满足皮肤伤口愈合应用的需求。羧甲基纤维素钠薄膜的吐温80浓度在0.05％至0.5％w范围内变化/ w，并进行了各种理化特性测试，例如吸附，水分吸收，侵蚀，水蒸气传输和水蒸气透过率，振动，热和形态分析。结果表明该制剂含有0.3％的w吐温80的/ w能够形成具有显着良好的吸附能力，降低的腐蚀百分率和高拉伸强度的膜，并且在膜表面形成“褶皱”。振动和热分析表明，亲水性和疏水性域均发生流化，这归因于配方中聚合物与表面活性剂和/或增塑剂部分之间新的“键合”的发展，尽管这不会影响转变温度，但会显着降低产生转变的能量，预期该转变可增加薄膜的弹性。聚合物和补间80的这种优化组合可以在加速受损后的皮肤再生过程中发挥有效作用。添加了0.3％w的羧甲基纤维素钠薄膜吐温80代表制造羧甲基纤维素钠的理想组合。