Schiff bases and their copper complexes have been previously studied for their anti-inflammatory, anti-tumor as well as anti-microbial activities. Schiff bases can be derivatized to gain photoluminiscence capacity. This property of the schiff bases enables the transfer of the electrons upon absorption of the light at a specific wavelength. In this study, we exploited this attribute of novel copper bearing schiff bases and tested their photodynamic biological activities. These compounds exerted photodynamic anti-inflammatory activities on the in vitro activated mammalian macrophages. Compared with salicylic acid control groups, these novel schiff bases had stronger activity which became more prominent with photo-induction. Moreover, they also had anti-microbial activity on gram negative bacteria E.coli and gram positive bacteria S.aureus.This anti-microbial activity was stronger than that of Neomycin on both bacterial strains. Our results suggest their potential use as anti-inflammatory and anti-microbial agents both in the dark as well as after photo-induction.

中文翻译：

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具有光动力学抗炎和抗微生物活性的新型含铜席夫碱。

希夫碱及其铜络合物的抗炎，抗肿瘤和抗微生物活性已有研究。Schiff碱可以衍生化以获得光致发光能力。席夫碱的这种性质使得在特定波长的光吸收后​​电子能够转移。在这项研究中，我们利用了新型含铜席夫碱的这一特性，并测试了它们的光动力生物活性。这些化合物对体外活化的哺乳动物巨噬细胞发挥光动力抗炎活性。与水杨酸对照组相比，这些新的席夫碱具有更强的活性，随着光诱导作用变得更加突出。此外，它们还对革兰氏阴性菌大肠杆菌和革兰氏阳性菌金黄色葡萄球菌具有抗菌活性。在两种细菌菌株上，这种抗微生物活性都比新霉素强。我们的结果表明，它们在黑暗中以及在光诱导后均可用作抗炎剂和抗微生物剂。