Light-mediated therapeutics have attracted considerable attention as a method for the treatment of ophthalmologic diseases, such as age-related macular degeneration, because of their non-invasiveness and the effectiveness to ameliorate the oxidative stress of retinal cells. However, the current phototherapeutic devices are opaque, bulky, and tethered forms, so they are not feasible for use in continuous treatment during the patient’s daily life. Herein, we report wireless, wearable phototherapeutic devices with red light-emitting diodes for continuous treatments. Red light-emitting diodes were formed to be conformal to three-dimensional surfaces of glasses and contact lenses. Furthermore, fabricated light-emitting diodes had either transparency or a miniaturized size so that the user’s view is not obstructed. Also, these devices were operated wirelessly with control of the light intensity. In addition, in-vitro and in-vivo tests using human retinal epithelial cells and a live rabbit demonstrated the effectiveness and reliable operation as phototherapeutic devices.

中文翻译：

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无线光疗隐形眼镜和带红色发光二极管的眼镜

作为治疗诸如年龄相关性黄斑变性的眼科疾病的方法，光介导疗法由于其无创性和减轻视网膜细胞氧化应激的功效而引起了极大的关注。然而，当前的光疗装置是不透明的，笨重的和栓系的形式，因此在患者的日常生活中将其用于连续治疗是不可行的。在此，我们报告了带有红色发光二极管的无线可穿戴光疗设备，用于连续治疗。红色发光二极管形成为与眼镜和隐形眼镜的三维表面共形。此外，制造的发光二极管具有透明性或小型化，因此不会妨碍使用者的视线。还，这些设备是在控制光强度的情况下进行无线操作的。此外，使用人视网膜上皮细胞和活兔进行的体外和体内试验证明了作为光疗设备的有效性和可靠的操作。