A Short Review of Synthetic Routes for the Antiepileptic Drug (R)-Lacosamide,Organic Process Research & Development

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A Short Review of Synthetic Routes for the Antiepileptic Drug (R)-Lacosamide
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2020-01-08 , DOI: 10.1021/acs.oprd.9b00373
Eswar K. Aratikatla _{1,

2} , Asish K. Bhattacharya _{1,

2}

Affiliation

The disease epilepsy affects people of all ages and is due to a chronic neurological disorder in the brain. According to a report by the World Health Organization, epilepsy is one of the most common global neurological diseases. (R)-Lacosamide (Vimpat) was introduced by UCB Pharma in 2008 for the treatment of partial-onset seizures in patients suffering from epilepsy. This review summarizes all of the available synthetic strategies reported for (R)-lacosamide, which will help medicinal chemists in the further development of its synthesis.

中文翻译：

概述抗癫痫药（R）-Lacosamide的合成途径。

癫痫病影响各个年龄段的人，并且归因于大脑中的慢性神经系统疾病。根据世界卫生组织的报告，癫痫病是最常见的全球神经系统疾病之一。UCB Pharma在2008年推出了（R）-Lacosamide（Vimpat），用于治疗癫痫患者的部分发作性癫痫发作。这篇综述总结了（R）-乳糖酰胺的所有可用合成策略，这将有助于药物化学家进一步发展其合成方法。

更新日期：2020-01-08

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