Cognition and behavior are thought to emerge from the connections and interactions among brain regions. The precise nature of these relationships remains elusive. Here we use tools provided by network control theory to determine how the structural connectivity profile of brain regions may shape individual variation in cognition. In a cohort of healthy young adults (n = 1066), we computed two fundamental brain regional control patterns, average and modal controllability, which index the degree of influence of a region over others. We first established that regional brain controllability measures were both reproducible and heritable. Regions with controllability profiles theoretically conducive to facilitating multiple cognitive operations were over-represented in higher-order resting-state networks. Finally, variation in regional controllability accounted for about 50% of interindividual variability in multiple cognitive domains. We conclude that controllability is a biologically plausible property of the structural connectome and provides a mechanistic explanation for how brain structural architecture may influence cognitive functions.

中文翻译：

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结构性大脑可控性的遗传性和认知相关性。

认知和行为被认为是从大脑区域之间的连接和相互作用中产生的。这些关系的确切性质仍然难以捉摸。在这里，我们使用网络控制理论提供的工具来确定大脑区域的结构连通性如何影响认知的个体差异。在一组健康的年轻人 (n = 1066) 中，我们计算了两个基本的大脑区域控制模式，平均可控性和模态可控性，它们对一个区域对其他区域的影响程度进行了索引。我们首先确定区域大脑可控性措施既可重复又可遗传。理论上有利于促进多种认知操作的可控性区域在高阶静息状态网络中被过度代表。最后，区域可控性的差异约占多个认知领域个体间差异的 50%。我们得出结论，可控性是结构连接组的生物学上合理的特性，并为大脑结构结构如何影响认知功能提供了机械解释。