当前位置：
X-MOL 学术
›
Drug Test. Anal.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Multimodal imaging of hallucinogens 25C- and 25I-NBOMe on blotter papers.
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-01-28 , DOI: 10.1002/dta.2751 Elias Lützen 1 , Michael Holtkamp 1 , Imke Stamme 2 , Robin Schmid 1 , Michael Sperling 1, 3 , Michael Pütz 2 , Uwe Karst 1
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-01-28 , DOI: 10.1002/dta.2751 Elias Lützen 1 , Michael Holtkamp 1 , Imke Stamme 2 , Robin Schmid 1 , Michael Sperling 1, 3 , Michael Pütz 2 , Uwe Karst 1
Affiliation
|
Due to the much lower production costs but similar effects to lysergic acid diethylamide (LSD), phenethylamine derivatives are sold as a cheaper replacement or deceptively as LSD itself. These potent hallucinogenic substances can lead to severe intoxication, thus a more profound understanding of their use is required. This includes the elucidation of the manufacturing processes for the commonly used blotter papers and the assessment of the risk of overdosing because of a heterogeneous distribution on the blotter papers. Besides the rapid detection of the analytes, the manufacturing process was elucidated by three different imaging techniques and liquid chromatography‐mass spectrometry (LC–MS). A blotter paper sample, containing the two hallucinogenic phenethylamine derivatives 25I‐NBOMe and 25C‐NBOMe, was analyzed by complementary techniques such as micro x‐ray fluorescence (μXRF), laser ablation (LA)‐inductively coupled plasma‐optical emission spectroscopy (ICP‐OES), matrix assisted laser desorption ionization (MALDI)‐MS, and with LC–MS after extraction. Using the signal from chlorine and iodine within the compounds, μXRF proved to be the fastest, cheapest and easiest method for identification, requiring no sample preparation at all. LA‐ICP‐OES provided three‐dimensional information of the elements in the blotter paper. These results helped to confirm the assumption that manufacturers spray the compounds onto the paper. Whereas μXRF and LA‐ICP‐OES detected signals for chlorine and iodine, MALDI‐MS‐imaging showed the molecular distribution of both analytes. LC–MS analyses as a complementary method support the imaging results. Quantitative results for different drug hotspots revealed a heterogeneous distribution of the drugs on the blotter paper implying an inherent risk of overdosing for consumers.
中文翻译：
在吸墨纸上对致幻剂25C-和25I-NBOMe进行多峰成像。
由于生产成本低得多，但效果与麦角酸二乙酰胺（LSD）相似，因此苯乙胺衍生物以便宜的替代品或LSD本身的欺骗性出售。这些强力的致幻物质会导致严重的中毒，因此需要对其使用有更深刻的了解。这包括阐明常用吸墨纸的制造工艺，以及评估由于吸墨纸上分布不均而导致用药过量的风险。除了快速检测分析物外，还通过三种不同的成像技术和液相色谱-质谱（LC-MS）阐明了制造过程。吸墨纸样品，其中包含两种致幻剂苯乙胺衍生物25I-NBOMe和25C-NBOMe，已通过补充技术进行了分析，例如微X射线荧光（μXRF），激光烧蚀（LA）电感耦合等离子体发射光谱（ICP-OES），基质辅助激光解吸电离（MALDI）-MS以及LC-提取后的MS。利用化合物中氯和碘的信号，μXRF被证明是最快，最便宜和最简单的鉴定方法，完全不需要样品制备。LA‐ICP‐OES提供了吸墨纸中元素的三维信息。这些结果有助于确认制造商将化合物喷在纸上的假设。μXRF和LA‐ICP‐OES检测到氯和碘的信号，而MALDI‐MS‐成像显示了两种分析物的分子分布。LC-MS分析作为补充方法可支持成像结果。
更新日期：2020-01-28
中文翻译：
在吸墨纸上对致幻剂25C-和25I-NBOMe进行多峰成像。
由于生产成本低得多，但效果与麦角酸二乙酰胺（LSD）相似，因此苯乙胺衍生物以便宜的替代品或LSD本身的欺骗性出售。这些强力的致幻物质会导致严重的中毒，因此需要对其使用有更深刻的了解。这包括阐明常用吸墨纸的制造工艺，以及评估由于吸墨纸上分布不均而导致用药过量的风险。除了快速检测分析物外，还通过三种不同的成像技术和液相色谱-质谱（LC-MS）阐明了制造过程。吸墨纸样品，其中包含两种致幻剂苯乙胺衍生物25I-NBOMe和25C-NBOMe，已通过补充技术进行了分析，例如微X射线荧光（μXRF），激光烧蚀（LA）电感耦合等离子体发射光谱（ICP-OES），基质辅助激光解吸电离（MALDI）-MS以及LC-提取后的MS。利用化合物中氯和碘的信号，μXRF被证明是最快，最便宜和最简单的鉴定方法，完全不需要样品制备。LA‐ICP‐OES提供了吸墨纸中元素的三维信息。这些结果有助于确认制造商将化合物喷在纸上的假设。μXRF和LA‐ICP‐OES检测到氯和碘的信号，而MALDI‐MS‐成像显示了两种分析物的分子分布。LC-MS分析作为补充方法可支持成像结果。
京公网安备 11010802027423号