Eight biomarkers on a novel strip for early diagnosis of acute myocardial infarction,Nanoscale Advances

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Eight biomarkers on a novel strip for early diagnosis of acute myocardial infarction
Nanoscale Advances ( IF 4.6 ) Pub Date : 2019/12/17 , DOI: 10.1039/c9na00644c
Li Huang _{1,

2,

3} , Yuanchang Zhang ₃ , Enben Su _{2,

3} , Yuan Liu ₁ , Yan Deng ₃ , Lian Jin ₃ , Zhu Chen ₃ , Song Li ₃ , Yongxiang Zhao ₄ , Nongyue He _{1,

2,

4}

Affiliation

Accurate detection of markers in human serum is important in the early diagnosis of acute myocardial infarction (AMI). This work presents a novel eight biomarker strip, which combines dry chemistry with a fluorescence lateral flow assay. Eight AMI markers were employed simultaneously for sensitive detection, including cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), uric acid (UA), myoglobin (Myo), creatine kinase-MB (CK-MB), and cardiac troponin I (cTnI). The strip offers the advantages of simple fabrication, convenience, time-saving detection and accurate assessment for AMI. Moreover, the strip possesses acceptable applicability for human serum. This proposed strategy establishes a remarkable platform for the construction of a multi-target detection strip that is feasible for accurate detection for real human serum samples.

中文翻译：

用于早期诊断急性心肌梗死的新型试纸上的八种生物标志物

准确检测人血清中的标志物对于急性心肌梗死（AMI）的早期诊断具有重要意义。这项工作提出了一种新颖的八生物标记物条，它将干化学与荧光侧流测定相结合。同时采用8种AMI标志物进行灵敏检测，包括胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）、尿酸（UA）、肌红蛋白（Myo） )、肌酸激酶-MB (CK-MB) 和心肌肌钙蛋白 I (cTnI)。该条带具有制作简单、检测方便、检测省时、AMI评估准确等优点。此外，该条对人血清具有可接受的适用性。该策略为构建多目标检测条建立了一个卓越的平台，可用于准确检测真实的人血清样本。

更新日期：2020-03-19

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