Cyrene™ is a green alternative to DMSO as a solvent for antibacterial drug discovery against ESKAPE pathogens,RSC Medicinal Chemistry

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Cyrene™ is a green alternative to DMSO as a solvent for antibacterial drug discovery against ESKAPE pathogens
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2019/12/17 , DOI: 10.1039/c9md00341j
Jason E. Camp _{1,

2,

3,

4,

5} , Simbarashe B. Nyamini _{1,

2,

3,

4} , Fraser J. Scott _{4,

6,

7,

8}

Affiliation

Dimethyl sulfoxide (DMSO) is currently employed across the biomedical field, from cryopreservation to in vitro assays, despite the fact that it has been shown to have an assortment of biologically relevant effects. The amphiphilic nature of DMSO along with its relatively low toxicity at dilute concentrations make it a challenging solvent to replace. A possible alternative is Cyrene™ (dihydrolevoglucosenone), an aprotic dipolar solvent that is derived from waste biomass. In addition to being a green solvent, Cyrene™ has comparable solvation properties and is reported to have low toxicity. Herein the abilities of the two solvents to solubilize drug compounds and to act as non-participatory vehicles in drug discovery for antibacterials are compared. It was demonstrate that the results of standardised antimicrobial susceptibility testing do not differ between drugs prepared from either Cyrene™ or DMSO stock. Moreover, in contrast to DMSO, Cyrene™ does not offer protection from ROS mediated killing of bacteria and may therefore be an improvement over DMSO as a vehicle in antimicrobial drug discovery.

中文翻译：

Cyrene™是DMSO的绿色替代品，可作为发现抗ESKAPE病原体的抗菌药物的溶剂

从冷冻保存到体外，二甲基亚砜（DMSO）目前已应用于整个生物医学领域分析方法，尽管事实表明它具有多种生物学相关的作用。DMSO的两亲性及其在低浓度下的较低毒性使其成为一种具有挑战性的溶剂。可能的替代方法是Cyrene™（二氢左旋葡萄糖苷），一种非质子传递的偶极溶剂，它来自废物生物质。除是绿色溶剂外，Cyrene™还具有可比的溶剂化性能，并且据报道毒性低。在本文中，比较了两种溶剂增溶药物化合物并在抗菌药物发现中充当非参与性载体的能力。结果表明，使用Cyrene™或DMSO原料制得的药物之间标准化的药敏试验结果没有差异。而且，与DMSO相比，

更新日期：2020-02-13

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