Nowadays, Fenton reaction-based chemodynamic therapy (CDT) strategies have drawn extensive attention as tumor-specific nanomedicine-based therapy. Nevertheless, current existing CDTs normally suffer from therapeutic bottlenecks such as the scavenging of hydroxyl radical (˙OH) by intracellular antioxidants and unideal therapeutic outcome of single treatment modality. Herein, we constructed novel all-in-one AFP nanoparticles (NPs) as CDT agents through a one-pot process for multifunctional nanotheranostics. The as-constructed AFP NPs could simultaneously produce ˙OH through the Fenton reaction and scavenge intracellular glutathione, functioning as self-reinforced CDT agents to achieve tumor-triggered enhanced CDT (ECDT). In addition, the AFP NPs possessed the capability of H2O2 and acid-boosted photoacoustic imaging and photothermal therapy, enabling a precise and effective tumor therapeutic outcome with minimal nonspecific damage in combination with ECDT. Our novel nanoplatform would open new perspectives on multi-functional CDT agents for accurate and non-invasive tumor theranostics.

中文翻译：

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具有光热和光声特性的谷胱甘肽消耗化学动力治疗剂，用于肿瘤治疗。

如今，基于芬顿反应的化学动力学疗法（CDT）策略已作为基于肿瘤的纳米药物疗法得到了广泛的关注。然而，当前现有的CDT通常会遇到治疗瓶颈，例如细胞内抗氧化剂清除羟基（˙OH）以及单一治疗方式的不理想治疗结果。在这里，我们通过一锅法为多功能纳米热学技术构建了新颖的多合一AFP纳米粒子（NPs）作为CDT试剂。如此构建的AFP NPs可以通过Fenton反应同时产生˙OH，并清除细胞内的谷胱甘肽，充当自我增强的CDT剂，从而实现肿瘤触发的增强CDT（ECDT）。此外，AFP NP具有H2O2的功能以及酸增强的光声成像和光热疗法，与ECDT结合使用，可实现精确有效的肿瘤治疗结果，同时将非特异性损害降至最低。我们的新型纳米平台将为多功能CDT试剂打开新的视野，以实现准确而无创的肿瘤治疗。